Coagulation Test Changes Associated With Acute Normovolemic Hemodilution in Cardiac Surgery
| Status: | Completed |
|---|---|
| Conditions: | Hematology |
| Therapuetic Areas: | Hematology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 1/9/2019 |
| Start Date: | January 31, 2018 |
| End Date: | October 11, 2018 |
The researchers are trying to reduce the need for blood transfusions in subjects having
surgery that will involve the use of cardiopulmonary bypass. A unit of whole blood will be
removed as part of their standard of care prior to going on cardiopulmonary bypass (CPB).
This unit is given back to the subject post CPB. This has been shown to reduce the need for
blood transfusion in patients.
surgery that will involve the use of cardiopulmonary bypass. A unit of whole blood will be
removed as part of their standard of care prior to going on cardiopulmonary bypass (CPB).
This unit is given back to the subject post CPB. This has been shown to reduce the need for
blood transfusion in patients.
Subjects will be asked to allow the researchers to take the blood left over from normal
standard of care blood draws and do coagulation testing. If clinically indicated, the blood,
about 2 units, will be withdrawn from the subject. The researchers will also collect 8 ml
(less than two teaspoons) of blood through the catheter that was placed as part of standard
of care.
standard of care blood draws and do coagulation testing. If clinically indicated, the blood,
about 2 units, will be withdrawn from the subject. The researchers will also collect 8 ml
(less than two teaspoons) of blood through the catheter that was placed as part of standard
of care.
Inclusion Criteria:
- Undergoing a cardiac surgical procedure utilizing cardiopulmonary bypass
- Permission to use medical records in research
Exclusion Criteria:
- Unable to grant informed consent or comply with study procedure
- Patient refusal of ANH withdrawal.
- Undergoing emergency open heart-surgery
- CPB time is expected to be < 30 minutes
- Less than 18 years of age
- Pregnant
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