Evaluation of Appeal and Impact of E-Cigarettes Among Chronic Smokers With Smoking-Related Cancers

The aim of the study is to determine the appeal of e-cigarettes compared to combustible
cigarettes as measured by the degree to which patients succeed in reducing their cigarette
consumption over the 9 weeks they are supplied with product, along with their consumption of
e-cigarettes. We will measure past use of e-cigarettes and cigarettes at baseline, 3, 6, 9,
and 12 weeks. We will also assess the effect of e-cigarette substitution on toxicity by
measuring expired carbon monoxide and urine NNAL, a carcinogenic metabolite of cigarette
smoke.

Inclusion Criteria:

1. Histological or cytological diagnosis of lung, head & neck, or bladder cancer within
the past 5 years.

2. AJCC stages I-IV

3. Daily Smoking (at least 10 cigarettes per day for 10 years) and breath CO greater than
or equal to 9 ppm

4. Does not wish to quit smoking now (anyone wishing to quit smoking will be referred for
smoking cessation counselling through the DHMC program)

5. May be receiving anti-cancer agents

6. Age 18 or older

7. Fluent in English;

8. Patient must be capable and willing to provide informed written consent for study
participation;

9. Able to participate in study visits

Exclusion Criteria:

1. Cancer surgery planned in the next 9 weeks;

2. Treatment with radiation planned for the next 9 weeks,

3. Actively trying to quit smoking, or planning to in the next 30 days. (If a subject
reports that they plan to quit smoking in the next 30 days, we will call them after
the 30 days to see if they are still trying to quit.)

4. Any use of e-cigarettes in the past 30 days,

5. Pregnant or trying to get pregnant.