Exploration of DNA Methylation as a Marker for Early Detection of High Grade Serous Epithelial Ovarian Cancer

This study has two phases: "Discovery" cohort and "Validation" cohort.

The "Discovery" phase of this study will obtain tissue samples in a retrospective manner. The
investigators will perform genome-scale DNA Methylation analysis to obtain a panel of
candidate methylated DNA biomarkers. Twenty archival primary serous epithelial ovarian cancer
and twenty archival normal ovarian and salpingeal tissues will be identified by running a
report of diagnosis.

During the "Validation" phase of this study, blood and tissue samples will be obtained in a
prospective manner. The patients will be undergoing consultation for undiagnosed pelvic mass
and are being scheduled for a diagnostic laparoscopic biopsy. At the time of their
consultation, patients will be recruited and consented for this phase of the study.

Inclusion Criteria:

- Female

- 18 years of age and older

- Women with an undiagnosed pelvic mass who need to undergo diagnostic laparoscopic
surgery

Exclusion Criteria:

- Male

- Under 18 years of age

- Women who can not give informed consent