Certolizumab in Crohn's Disease Patients With Loss of Response or Intolerance to Infliximab



Status:Completed
Conditions:Gastrointestinal, Crohns Disease
Therapuetic Areas:Gastroenterology
Healthy:No
Age Range:18 - Any
Updated:8/9/2018
Start Date:April 2006
End Date:April 2008

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Trial Summary
Trial Overview
Inclusion Criteria

Phase IIIb Open-label Induction and Double-blind Comparison of 2 Maintenance Schedules Evaluating Clinical Benefit and Tolerability of Certolizumab Pegol in Crohn's Disease Patients With Prior Loss of Response or Intolerance to Infliximab

To assess the clinical efficacy of subcutaneous (sc) certolizumab pegol administration over
26 weeks in patients suffering from Crohn's Disease (CD) and previously treated with
infliximab


Inclusion Criteria:

- Subjects with Crohn's Disease

- Previous treatment failure to Infliximab (intolerance and/or no response)

Exclusion Criteria:

- Obstructive intestinal strictures

- Recent bowel resection

- Proctocolectomy or total colectomy

- Current total parenteral nutrition

- Short bowel syndrome

- All concomitant diseases or pathological conditions that could interfere with Crohn's
disease assessment or to be harmful for the well being of the patient

- Previous clinical trials and previous biological therapy that could interfere with the
results in the present clinical trial
We found this trial at
32
sites
Clinical Trial Facility in Baton Rouge Louisiana
Baton Rouge, Louisiana 70809
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Baton Rouge, LA
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Clinical Trial Facility in Atlanta Georgia
Atlanta, Georgia
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Atlanta, GA
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Clinical Trial Facility in Baltimore Maryland
Baltimore, Maryland
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Baltimore, MD
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Clinical Trial Facility in Boston Massachusetts
Boston, Massachusetts
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Boston, MA
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Clinical Trial Facility in Chapel Hill North Carolina
Chapel Hill, North Carolina
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Chapel Hill, NC
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Clinical Trial Facility in Charleston South Carolina
Charleston, South Carolina 29412
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Charleston, SC
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Clinical Trial Facility in Charlotte North Carolina
Charlotte, North Carolina 28207
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Charlotte, NC
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Clinical Trial Facility in Chicago Illinois
Chicago, Illinois
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Chicago, IL
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Clinical Trial Facility in Cincinnati Ohio
Cincinnati, Ohio
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Cincinnati, OH
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Clinical Trial Facility in Cleveland Ohio
Cleveland, Ohio
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Cleveland, OH
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Clinical Trial Facility in Dallas Texas
Dallas, Texas 75390
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Dallas, TX
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Clinical Trial Facility in Gainesville Florida
Gainesville, Florida 32610
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Gainesville, FL
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Clinical Trial Facility in Galveston Texas
Galveston, Texas 77555
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Galveston, TX
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Clinical Trial Facility in Germantown Tennessee
Germantown, Tennessee 38138
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Germantown, TN
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Clinical Trial Facility in Great Neck New York
Great Neck, New York 11021
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Great Neck, NY
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Clinical Trial Facility in Houston Texas
Houston, Texas
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Houston, TX
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Clinical Trial Facility in Indianapolis Indiana
Indianapolis, Indiana 46202
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Indianapolis, IN
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Clinical Trial Facility in Innsbruck
Innsbruck,
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Innsbruck,
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Clinical Trial Facility in Kingsport Tennessee
Kingsport, Tennessee 37660
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Kingsport, TN
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Clinical Trial Facility in Lexington Kentucky
Lexington, Kentucky
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Lexington, KY
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Clinical Trial Facility in Lincoln Nebraska
Lincoln, Nebraska 68515
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Lincoln, NE
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Clinical Trial Facility in Louisville Kentucky
Louisville, Kentucky 40202
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Louisville, KY
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Clinical Trial Facility in Milwaukee Wisconsin
Milwaukee, Wisconsin 53226
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Milwaukee, WI
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Clinical Trial Facility in Nashville Tennessee
Nashville, Tennessee 37232
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Nashville, TN
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Clinical Trial Facility in New York New York
New York, New York 10032
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New York, NY
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Clinical Trial Facility in Oklahoma City Oklahoma
Oklahoma City, Oklahoma
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Oklahoma City, OK
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Clinical Trial Facility in Philadelphia Pennsylvania
Philadelphia, Pennsylvania
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Philadelphia, PA
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Clinical Trial Facility in Pittsburgh Pennsylvania
Pittsburgh, Pennsylvania
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Pittsburgh, PA
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Clinical Trial Facility in Portland Oregon
Portland, Oregon
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Portland, OR
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Clinical Trial Facility in Rochester Minnesota
Rochester, Minnesota 55905
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Rochester, MN
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Clinical Trial Facility in San Francisco California
San Francisco, California
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San Francisco, CA
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Clinical Trial Facility in Seattle Washington
Seattle, Washington 98105
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Seattle, WA
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