Mupirocin-Iodophor ICU Decolonization Swap Out Trial



Status:Recruiting
Conditions:Infectious Disease
Therapuetic Areas:Immunology / Infectious Diseases
Healthy:No
Age Range:Any
Updated:8/8/2018
Start Date:May 1, 2017
End Date:December 2023
Contact:Katie Haffenreffer
Email:Katie_Haffenreffer@hphc.org
Phone:617-867-4807

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Cluster-randomized Non-inferiority Trial Comparing Mupirocin vs Iodophor for Nasal Decolonization of ICU Patients to Assess Impact on S. Aureus Clinical Cultures and All-cause Bloodstream Infection During Routine Chlorhexidine Bathing

The Swap Out Trial is a cluster randomized controlled trial of HCA hospitals, evaluating the
non-inferiority of two decolonization regimens:

Arm 1 Routine Care: ICU nasal decolonization with mupirocin twice daily for 5 days in the
context of chlorhexidine for daily bathing; Arm 2 Intervention: ICU nasal decolonization with
iodophor twice daily for 5 days in the context of chlorhexidine for daily bathing Note: that
enrolled "subjects" represents 137 individual HCA Hospitals (representing ~235 ICUs) that
have been randomized.


Inclusion Criteria:

- Inclusion criteria includes all U.S. HCA hospitals with an adult ICU;

- Note: Unit of randomization is the hospital, but the participants are hospital adult
ICUs

- All patients within adult ICUs are included, including rare patients <18 years and
>=12 years.

Exclusion Criteria:

- Exclusion criteria includes ICUs with an average length of stay of less than 2 days;

- HCA hospitals that are not able to transfer or merge data into the centralized data
warehouse for the baseline and intervention periods of the study are also excluded.
We found this trial at
137
sites
1719 East 19th Avenue
Denver, Colorado 80218
(303) 839-6000
Presbyterian - St. Luke's Medical Center Presbyterian/St. Luke's Medical Center and the Rocky Mountain Hospital...
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7777 Forest Ln # C840
Dallas, Texas 75230
(972) 566-7000
Medical City Dallas Hospital If you have concerns for your health, that of a family...
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211 4th Street
Alexandria, Louisiana 71301
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Arlington, Texas 76015
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Atlantis, Florida 33462
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Augusta, Georgia 30909
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1501 S Potomac St
Aurora, Colorado 80012
(303) 695-2600
Medical Center of Aurora At The Medical Center of Aurora and Centennial Medical Plaza patients...
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Austin, Texas 78745
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Austin, Texas 78758
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Aventura, Florida 33180
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Belton, Missouri 64012
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Blacksburg, Virginia 24060
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Bountiful, Utah 84010
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Bowling Green, Kentucky 42104
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Bradenton, Florida 34209
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Brandon, Florida 33511
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Brooksville, Florida 34613
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Brownsville, Texas 78526
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Caldwell, Idaho 83605
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Cartersville, Georgia 30120
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Charleston, South Carolina 29406
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Chattanooga, Tennessee 37404
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Chattanooga, Tennessee 37412
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Conroe, Texas 77304
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Corpus Christi, Texas 78411
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Covington, Louisiana 70433
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Denton, Texas 76210
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Denver, Colorado 80110
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Denver, Colorado 80124
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4567 E 9th Ave
Denver, Colorado 80220
(303) 320-2121
Rose Medical Center Well known as a Denver institution and a 9th Avenue landmark for...
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Derry, New Hampshire 03038
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Dublin, Georgia 31021
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El Paso, Texas 79902
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El Paso, Texas 79925
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Englewood, Florida 34223
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Fort Pierce, Florida 34950
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Fort Worth, Texas 76104
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Fredericksburg, Pennsylvania 22408
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Hopewell, Virginia 23860
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Houston, Texas 77082
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14000 Fivay Road
Hudson, Florida 34667
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Idaho Falls, Idaho 83404
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Independence, Missouri 64057
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Irving, Texas 75039
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Jacksonville, Florida 32216
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2316 E Meyer Blvd
Kansas City, Missouri 64132
(816) 276-4000
Research Medical Center Research Medical Center offers hospital and health clinic services across three Kansas...
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Kingwood, Texas
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Kissimmee, Florida 34741
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Low Moor, Virginia 24457
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13001 Southern Boulevard
Loxahatchee Groves, Florida 33470
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Macon, Georgia 31217
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McAllen, Texas 78503
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McKinney, Texas 75069
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Ocala, Florida 34474
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5475 South 500 East
Ogden, Utah 84405
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Okeechobee, Florida 34972
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750 West 800 North
Orem, Utah 84057
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5721 W 119th St
Overland Park, Kansas 66209
(913) 498-6000
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Overland Park, Kansas 66215
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Panama City, Florida 32405
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Pasadena, Texas 77504
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Portsmouth, New Hampshire 03801
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