Mupirocin-Iodophor ICU Decolonization Swap Out Trial



Status:Recruiting
Conditions:Infectious Disease
Therapuetic Areas:Immunology / Infectious Diseases
Healthy:No
Age Range:Any
Updated:8/8/2018
Start Date:May 1, 2017
End Date:December 2023
Contact:Katie Haffenreffer
Email:Katie_Haffenreffer@hphc.org
Phone:617-867-4807

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Trial Summary
Trial Overview
Inclusion Criteria

Cluster-randomized Non-inferiority Trial Comparing Mupirocin vs Iodophor for Nasal Decolonization of ICU Patients to Assess Impact on S. Aureus Clinical Cultures and All-cause Bloodstream Infection During Routine Chlorhexidine Bathing

The Swap Out Trial is a cluster randomized controlled trial of HCA hospitals, evaluating the
non-inferiority of two decolonization regimens:

Arm 1 Routine Care: ICU nasal decolonization with mupirocin twice daily for 5 days in the
context of chlorhexidine for daily bathing; Arm 2 Intervention: ICU nasal decolonization with
iodophor twice daily for 5 days in the context of chlorhexidine for daily bathing Note: that
enrolled "subjects" represents 137 individual HCA Hospitals (representing ~235 ICUs) that
have been randomized.


Inclusion Criteria:

- Inclusion criteria includes all U.S. HCA hospitals with an adult ICU;

- Note: Unit of randomization is the hospital, but the participants are hospital adult
ICUs

- All patients within adult ICUs are included, including rare patients <18 years and
>=12 years.

Exclusion Criteria:

- Exclusion criteria includes ICUs with an average length of stay of less than 2 days;

- HCA hospitals that are not able to transfer or merge data into the centralized data
warehouse for the baseline and intervention periods of the study are also excluded.
We found this trial at
137
sites
Fairview Park
Dublin, Georgia 31021
513
mi
from 43215
Dublin, GA
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Medical City Dallas Hospital
7777 Forest Ln # C840
Dallas, Texas 75230
(972) 566-7000
Medical City Dallas Hospital If you have concerns for your health, that of a family...
904
mi
from 43215
Dallas, TX
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Presbyterian - St. Luke's Medical Center
1719 East 19th Avenue
Denver, Colorado 80218
(303) 839-6000
Presbyterian - St. Luke's Medical Center Presbyterian/St. Luke's Medical Center and the Rocky Mountain Hospital...
1162
mi
from 43215
Denver, CO
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Rapides Regional Medical Center
211 4th Street
Alexandria, Louisiana 71301
797
mi
from 43215
Alexandria, LA
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Medical Center of Arlington
Arlington, Texas 76015
?
mi
from 43215
Arlington, TX
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JFK Medical Center
Atlantis, Florida 33462
940
mi
from 43215
Atlantis, FL
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Doctors Hospital of Augusta
Augusta, Georgia 30909
451
mi
from 43215
Augusta, GA
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Medical Center of Aurora
1501 S Potomac St
Aurora, Colorado 80012
(303) 695-2600
Medical Center of Aurora At The Medical Center of Aurora and Centennial Medical Plaza patients...
1154
mi
from 43215
Aurora, CO
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South Austin Hospital
Austin, Texas 78745
1065
mi
from 43215
Austin, TX
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North Austin Medical Center
Austin, Texas 78758
1065
mi
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Austin, TX
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Aventura Hospital
Aventura, Florida 33180
?
mi
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Aventura, FL
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Belton Regional Medical Center
Belton, Missouri 64012
?
mi
from 43215
Belton, MO
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LewisGale Hospital - Montgomery
Blacksburg, Virginia 24060
248
mi
from 43215
Blacksburg, VA
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Lakeview Hospital
Bountiful, Utah 84010
?
mi
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Bountiful, UT
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Greenview Regional Hospital
Bowling Green, Kentucky 42104
?
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Bowling Green, KY
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Blake Medical Center
Bradenton, Florida 34209
861
mi
from 43215
Bradenton, FL
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Brandon Regional
Brandon, Florida 33511
832
mi
from 43215
Brandon, FL
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Oak Hill Hospital
Brooksville, Florida 34613
?
mi
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Brooksville, FL
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Valley Regional Medical Center
Brownsville, Texas 78526
1280
mi
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Brownsville, TX
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West Valley Medical Center
Caldwell, Idaho 83605
1740
mi
from 43215
Caldwell, ID
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Cartersville Medical Center
Cartersville, Georgia 30120
412
mi
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Cartersville, GA
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Trident Regional Medical Center
Charleston, South Carolina 29406
?
mi
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Charleston, SC
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Parkridge Medical Center
Chattanooga, Tennessee 37404
362
mi
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Chattanooga, TN
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Parkridge East Hospital
Chattanooga, Tennessee 37412
363
mi
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Chattanooga, TN
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Conroe Regional Medical Center
Conroe, Texas 77304
966
mi
from 43215
Conroe, TX
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Corpus Christi Medical Center - Doctor's
Corpus Christi, Texas 78411
?
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Corpus Christi, TX
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Corpus Christi Medical Center - The Heart Hospital
Corpus Christi, Texas 78412
?
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Corpus Christi, TX
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Lakeview Regional Medical Center
Covington, Louisiana 70433
?
mi
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Covington, LA
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Denton Regional Medical Center
Denton, Texas 76210
?
mi
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Denton, TX
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Swedish Medical Center
Denver, Colorado 80110
1164
mi
from 43215
Denver, CO
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Sky Ridge Medical Center
Denver, Colorado 80124
1161
mi
from 43215
Denver, CO
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Rose Medical Center
4567 E 9th Ave
Denver, Colorado 80220
(303) 320-2121
Rose Medical Center Well known as a Denver institution and a 9th Avenue landmark for...
1158
mi
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Denver, CO
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Parkland Medical Center
Derry, New Hampshire 03038
637
mi
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Derry, NH
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Las Palmas Medical Center
El Paso, Texas 79902
1424
mi
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El Paso, TX
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Del Sol Medical Center
El Paso, Texas 79925
1424
mi
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El Paso, TX
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Englewood Community Hospital
Englewood, Florida 34223
?
mi
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Englewood, FL
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Lawnwood Regional Medical Center
Fort Pierce, Florida 34950
878
mi
from 43215
Fort Pierce, FL
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Fort Walton Medical Center
Fort Walton Beach, Florida 32547
690
mi
from 43215
Fort Walton Beach, FL
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Plaza Medical Center of Fort Worth
Fort Worth, Texas 76104
937
mi
from 43215
Fort Worth, TX
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Spotsylvania Regional Medical Center
Fredericksburg, Pennsylvania 22408
?
mi
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Fredericksburg, PA
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North Florida Regional Medical Center
Gainesville, Florida 32605
711
mi
from 43215
Gainesville, FL
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Garden Park Medical Center
Gulfport, Mississippi 39503
745
mi
from 43215
Gulfport, MS
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Hendersonville Medical Center
Hendersonville, Tennessee 37075
319
mi
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Hendersonville, TN
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Summit Medical Center
Hermitage, Tennessee 37076
325
mi
from 43215
Hermitage, TN
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John Randolph Medical Center
Hopewell, Virginia 23860
359
mi
from 43215
Hopewell, VA
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East Houston Regional Medical Center
Houston, Texas 77015
?
mi
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Houston, TX
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West Houston Medical Center
Houston, Texas 77082
991
mi
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Houston, TX
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Regional Medical Center Bayonet Point
14000 Fivay Road
Hudson, Florida 34667
801
mi
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Hudson, FL
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Eastern Idaho Regional
Idaho Falls, Idaho 83404
?
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Idaho Falls, ID
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Centerpoint Medical Center LLC
Independence, Missouri 64057
606
mi
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Independence, MO
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Las Colinas Medical Center
Irving, Texas 75039
914
mi
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Irving, TX
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Memorial Hospital Jacksonville
Jacksonville, Florida 32216
673
mi
from 43215
Jacksonville, FL
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Research Medical Center
2316 E Meyer Blvd
Kansas City, Missouri 64132
(816) 276-4000
Research Medical Center Research Medical Center offers hospital and health clinic services across three Kansas...
617
mi
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Kansas City, MO
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Kingwood Medical Center
Kingwood, Texas
969
mi
from 43215
Kingwood, TX
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Osceola Regional Med Ctr
Kissimmee, Florida 34741
810
mi
from 43215
Kissimmee, FL
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Poinciana Medical Center
Kissimmee, Florida 34758
810
mi
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Kissimmee, FL
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Lake City Medical Center
Lake City, Florida 32055
675
mi
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Lake City, FL
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Largo Medical Center
Largo, Florida 33770
833
mi
from 43215
Largo, FL
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Sunrise Hospital and Medical Center
Las Vegas, Nevada 89109
1758
mi
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Las Vegas, NV
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Mountainview Hospital - Vegas
Las Vegas, Nevada 89128
?
mi
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Las Vegas, NV
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Southern Hills Hospital - Vegas
Las Vegas, Nevada 89148
1756
mi
from 43215
Las Vegas, NV
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Lee's Summit Medical Center
Lee's Summit, Missouri 64063
610
mi
from 43215
Lee's Summit, MO
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Medical Center of Lewisville
Lewisville, Texas 75057
?
mi
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Lewisville, TX
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LewisGale Hospital-Alleghany
Low Moor, Virginia 24457
226
mi
from 43215
Low Moor, VA
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Palms West Hospital
13001 Southern Boulevard
Loxahatchee Groves, Florida 33470
931
mi
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Loxahatchee Groves, FL
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Coliseum Medical Centers - Main
Macon, Georgia 31217
?
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Macon, GA
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Coliseum Medical Centers - Northside
Macon, Georgia 31217
?
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Macon, GA
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Northwest Medical Center
Margate, Florida 33063
961
mi
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Margate, FL
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Rio Grande Regional Hospital
McAllen, Texas 78503
1291
mi
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McAllen, TX
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Medical Center of McKinney
McKinney, Texas 75069
?
mi
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McKinney, TX
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Mercy Hospital
Miami, Florida 33133
996
mi
from 43215
Miami, FL
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Kendall Regional Medical Center
Miami, Florida 33175
994
mi
from 43215
Miami, FL
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Grand Strand Regional Medical Center
Myrtle Beach, South Carolina 29572
487
mi
from 43215
Myrtle Beach, SC
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Stonecrest Medical Center
Nashville, Tennessee 37167
332
mi
from 43215
Nashville, TN
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Centennial Medical Center
Nashville, Tennessee 37203
333
mi
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Nashville, TN
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Skyline Medical Center
Nashville, Tennessee 37207
?
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Nashville, TN
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Southern Hills Medical Center
Nashville, Tennessee 37211
?
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Nashville, TN
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Tulane University Hospital & Clinic
New Orleans, Louisiana 70112
798
mi
from 43215
New Orleans, LA
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Twin Cities Hospital
Niceville, Florida 32578
681
mi
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Niceville, FL
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North Hills Hospital
North Richland Hills, Texas 76180
929
mi
from 43215
North Richland Hills, TX
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Ocala Regional Medical Center
Ocala, Florida 34480
751
mi
from 43215
Ocala, FL
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West Marion Community Hospital
Ocala, Florida 34474
746
mi
from 43215
Ocala, FL
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Ogden Regional Medical Center
5475 South 500 East
Ogden, Utah 84405
1514
mi
from 43215
Ogden, UT
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Raulerson Hospital
Okeechobee, Florida 34972
?
mi
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Okeechobee, FL
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Orange Park Medical Center
Orange Park, Florida 32073
769
mi
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Orange Park, FL
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Timpanogos Regional Medical Center
750 West 800 North
Orem, Utah 84057
1508
mi
from 43215
Orem, UT
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Menorah Medical Center
5721 W 119th St
Overland Park, Kansas 66209
(913) 498-6000
Menorah Medical Center Menorah Medical Center (MMC), a full-service, acute care hospital located on the...
623
mi
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Overland Park, KS
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Overland Park Regional Medical Center
Overland Park, Kansas 66215
624
mi
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Overland Park, KS
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Gulf Coast Medical Center
Panama City, Florida 32405
693
mi
from 43215
Panama City, FL
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Bayshore Medical Center
Pasadena, Texas 77504
989
mi
from 43215
Pasadena, TX
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Mountain View Hospital - Utah
Payson, Utah 84651
?
mi
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Payson, UT
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West Florida Hospital
Pensacola, Florida 32514
700
mi
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Pensacola, FL
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The Medical Center of Plano
Plano, Texas 75075
896
mi
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Plano, TX
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Plantation General Hospital
Plantation, Florida 33317
?
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Plantation, FL
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Westside Regional Medical Center
Plantation, Florida 33324
970
mi
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Plantation, FL
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Fawcett Memorial Hospital
Port Charlotte, Florida 33952
899
mi
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Port Charlotte, FL
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St Lucie Medical Center
Port Saint Lucie, Florida 34952
888
mi
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Port Saint Lucie, FL
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Portsmouth Regional Hospital
Portsmouth, New Hampshire 03801
668
mi
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Portsmouth, NH
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LewisGale Hospital - Pulaski
Pulaski, Virginia 24301
235
mi
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Pulaski, VA
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Reston Hospital
Reston, Virginia 20190
310
mi
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Reston, VA
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Henrico Doctors' Hospital - Retreat Campus
Richmond, Virginia 23220
?
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Richmond, VA
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