Mupirocin-Iodophor ICU Decolonization Swap Out Trial



Status:Recruiting
Conditions:Infectious Disease
Therapuetic Areas:Immunology / Infectious Diseases
Healthy:No
Age Range:Any
Updated:8/8/2018
Start Date:May 1, 2017
End Date:December 2023
Contact:Katie Haffenreffer
Email:Katie_Haffenreffer@hphc.org
Phone:617-867-4807

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Trial Summary
Trial Overview
Inclusion Criteria

Cluster-randomized Non-inferiority Trial Comparing Mupirocin vs Iodophor for Nasal Decolonization of ICU Patients to Assess Impact on S. Aureus Clinical Cultures and All-cause Bloodstream Infection During Routine Chlorhexidine Bathing

The Swap Out Trial is a cluster randomized controlled trial of HCA hospitals, evaluating the
non-inferiority of two decolonization regimens:

Arm 1 Routine Care: ICU nasal decolonization with mupirocin twice daily for 5 days in the
context of chlorhexidine for daily bathing; Arm 2 Intervention: ICU nasal decolonization with
iodophor twice daily for 5 days in the context of chlorhexidine for daily bathing Note: that
enrolled "subjects" represents 137 individual HCA Hospitals (representing ~235 ICUs) that
have been randomized.


Inclusion Criteria:

- Inclusion criteria includes all U.S. HCA hospitals with an adult ICU;

- Note: Unit of randomization is the hospital, but the participants are hospital adult
ICUs

- All patients within adult ICUs are included, including rare patients <18 years and
>=12 years.

Exclusion Criteria:

- Exclusion criteria includes ICUs with an average length of stay of less than 2 days;

- HCA hospitals that are not able to transfer or merge data into the centralized data
warehouse for the baseline and intervention periods of the study are also excluded.
We found this trial at
137
sites
Poinciana Medical Center
Kissimmee, Florida 34758
2556
mi
from 98109
Kissimmee, FL
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Medical City Dallas Hospital
7777 Forest Ln # C840
Dallas, Texas 75230
(972) 566-7000
Medical City Dallas Hospital If you have concerns for your health, that of a family...
1675
mi
from 98109
Dallas, TX
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Presbyterian - St. Luke's Medical Center
1719 East 19th Avenue
Denver, Colorado 80218
(303) 839-6000
Presbyterian - St. Luke's Medical Center Presbyterian/St. Luke's Medical Center and the Rocky Mountain Hospital...
1020
mi
from 98109
Denver, CO
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Rapides Regional Medical Center
211 4th Street
Alexandria, Louisiana 71301
1933
mi
from 98109
Alexandria, LA
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Medical Center of Arlington
Arlington, Texas 76015
?
mi
from 98109
Arlington, TX
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JFK Medical Center
Atlantis, Florida 33462
2698
mi
from 98109
Atlantis, FL
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Doctors Hospital of Augusta
Augusta, Georgia 30909
2296
mi
from 98109
Augusta, GA
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Medical Center of Aurora
1501 S Potomac St
Aurora, Colorado 80012
(303) 695-2600
Medical Center of Aurora At The Medical Center of Aurora and Centennial Medical Plaza patients...
1028
mi
from 98109
Aurora, CO
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South Austin Hospital
Austin, Texas 78745
1770
mi
from 98109
Austin, TX
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North Austin Medical Center
Austin, Texas 78758
1770
mi
from 98109
Austin, TX
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Aventura Hospital
Aventura, Florida 33180
?
mi
from 98109
Aventura, FL
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Belton Regional Medical Center
Belton, Missouri 64012
?
mi
from 98109
Belton, MO
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LewisGale Hospital - Montgomery
Blacksburg, Virginia 24060
2254
mi
from 98109
Blacksburg, VA
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Lakeview Hospital
Bountiful, Utah 84010
?
mi
from 98109
Bountiful, UT
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Greenview Regional Hospital
Bowling Green, Kentucky 42104
?
mi
from 98109
Bowling Green, KY
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Blake Medical Center
Bradenton, Florida 34209
2543
mi
from 98109
Bradenton, FL
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Brandon Regional
Brandon, Florida 33511
2535
mi
from 98109
Brandon, FL
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Oak Hill Hospital
Brooksville, Florida 34613
?
mi
from 98109
Brooksville, FL
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Valley Regional Medical Center
Brownsville, Texas 78526
2018
mi
from 98109
Brownsville, TX
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West Valley Medical Center
Caldwell, Idaho 83605
386
mi
from 98109
Caldwell, ID
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Cartersville Medical Center
Cartersville, Georgia 30120
2142
mi
from 98109
Cartersville, GA
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Trident Regional Medical Center
Charleston, South Carolina 29406
?
mi
from 98109
Charleston, SC
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Parkridge Medical Center
Chattanooga, Tennessee 37404
2083
mi
from 98109
Chattanooga, TN
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Parkridge East Hospital
Chattanooga, Tennessee 37412
2089
mi
from 98109
Chattanooga, TN
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Conroe Regional Medical Center
Conroe, Texas 77304
1858
mi
from 98109
Conroe, TX
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Corpus Christi Medical Center - Doctor's
Corpus Christi, Texas 78411
?
mi
from 98109
Corpus Christi, TX
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Corpus Christi Medical Center - The Heart Hospital
Corpus Christi, Texas 78412
?
mi
from 98109
Corpus Christi, TX
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Lakeview Regional Medical Center
Covington, Louisiana 70433
?
mi
from 98109
Covington, LA
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Denton Regional Medical Center
Denton, Texas 76210
?
mi
from 98109
Denton, TX
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Swedish Medical Center
Denver, Colorado 80110
1023
mi
from 98109
Denver, CO
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Sky Ridge Medical Center
Denver, Colorado 80124
1020
mi
from 98109
Denver, CO
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Rose Medical Center
4567 E 9th Ave
Denver, Colorado 80220
(303) 320-2121
Rose Medical Center Well known as a Denver institution and a 9th Avenue landmark for...
1024
mi
from 98109
Denver, CO
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Parkland Medical Center
Derry, New Hampshire 03038
2457
mi
from 98109
Derry, NH
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Fairview Park
Dublin, Georgia 31021
2298
mi
from 98109
Dublin, GA
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Las Palmas Medical Center
El Paso, Texas 79902
1375
mi
from 98109
El Paso, TX
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Del Sol Medical Center
El Paso, Texas 79925
1376
mi
from 98109
El Paso, TX
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Englewood Community Hospital
Englewood, Florida 34223
?
mi
from 98109
Englewood, FL
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Lawnwood Regional Medical Center
Fort Pierce, Florida 34950
2645
mi
from 98109
Fort Pierce, FL
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Fort Walton Medical Center
Fort Walton Beach, Florida 32547
2227
mi
from 98109
Fort Walton Beach, FL
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Plaza Medical Center of Fort Worth
Fort Worth, Texas 76104
1661
mi
from 98109
Fort Worth, TX
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Spotsylvania Regional Medical Center
Fredericksburg, Pennsylvania 22408
?
mi
from 98109
Fredericksburg, PA
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North Florida Regional Medical Center
Gainesville, Florida 32605
2450
mi
from 98109
Gainesville, FL
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Garden Park Medical Center
Gulfport, Mississippi 39503
2121
mi
from 98109
Gulfport, MS
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Hendersonville Medical Center
Hendersonville, Tennessee 37075
1972
mi
from 98109
Hendersonville, TN
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Summit Medical Center
Hermitage, Tennessee 37076
1977
mi
from 98109
Hermitage, TN
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John Randolph Medical Center
Hopewell, Virginia 23860
2367
mi
from 98109
Hopewell, VA
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East Houston Regional Medical Center
Houston, Texas 77015
?
mi
from 98109
Houston, TX
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West Houston Medical Center
Houston, Texas 77082
1890
mi
from 98109
Houston, TX
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Regional Medical Center Bayonet Point
14000 Fivay Road
Hudson, Florida 34667
2497
mi
from 98109
Hudson, FL
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Eastern Idaho Regional
Idaho Falls, Idaho 83404
?
mi
from 98109
Idaho Falls, ID
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Centerpoint Medical Center LLC
Independence, Missouri 64057
1515
mi
from 98109
Independence, MO
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Las Colinas Medical Center
Irving, Texas 75039
1667
mi
from 98109
Irving, TX
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Memorial Hospital Jacksonville
Jacksonville, Florida 32216
2458
mi
from 98109
Jacksonville, FL
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Research Medical Center
2316 E Meyer Blvd
Kansas City, Missouri 64132
(816) 276-4000
Research Medical Center Research Medical Center offers hospital and health clinic services across three Kansas...
1508
mi
from 98109
Kansas City, MO
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Kingwood Medical Center
Kingwood, Texas
1883
mi
from 98109
Kingwood, TX
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Osceola Regional Med Ctr
Kissimmee, Florida 34741
2556
mi
from 98109
Kissimmee, FL
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Lake City Medical Center
Lake City, Florida 32055
2414
mi
from 98109
Lake City, FL
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Largo Medical Center
Largo, Florida 33770
2514
mi
from 98109
Largo, FL
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Sunrise Hospital and Medical Center
Las Vegas, Nevada 89109
876
mi
from 98109
Las Vegas, NV
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Mountainview Hospital - Vegas
Las Vegas, Nevada 89128
?
mi
from 98109
Las Vegas, NV
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Southern Hills Hospital - Vegas
Las Vegas, Nevada 89148
873
mi
from 98109
Las Vegas, NV
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Lee's Summit Medical Center
Lee's Summit, Missouri 64063
1519
mi
from 98109
Lee's Summit, MO
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Medical Center of Lewisville
Lewisville, Texas 75057
?
mi
from 98109
Lewisville, TX
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LewisGale Hospital-Alleghany
Low Moor, Virginia 24457
2229
mi
from 98109
Low Moor, VA
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Palms West Hospital
13001 Southern Boulevard
Loxahatchee Groves, Florida 33470
2685
mi
from 98109
Loxahatchee Groves, FL
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Coliseum Medical Centers - Main
Macon, Georgia 31217
?
mi
from 98109
Macon, GA
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Coliseum Medical Centers - Northside
Macon, Georgia 31217
?
mi
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Macon, GA
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Northwest Medical Center
Margate, Florida 33063
2708
mi
from 98109
Margate, FL
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Rio Grande Regional Hospital
McAllen, Texas 78503
1974
mi
from 98109
McAllen, TX
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Medical Center of McKinney
McKinney, Texas 75069
?
mi
from 98109
McKinney, TX
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Mercy Hospital
Miami, Florida 33133
2732
mi
from 98109
Miami, FL
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Kendall Regional Medical Center
Miami, Florida 33175
2724
mi
from 98109
Miami, FL
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Grand Strand Regional Medical Center
Myrtle Beach, South Carolina 29572
2435
mi
from 98109
Myrtle Beach, SC
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Stonecrest Medical Center
Nashville, Tennessee 37167
1970
mi
from 98109
Nashville, TN
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Centennial Medical Center
Nashville, Tennessee 37203
1971
mi
from 98109
Nashville, TN
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Skyline Medical Center
Nashville, Tennessee 37207
?
mi
from 98109
Nashville, TN
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Southern Hills Medical Center
Nashville, Tennessee 37211
?
mi
from 98109
Nashville, TN
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Tulane University Hospital & Clinic
New Orleans, Louisiana 70112
2099
mi
from 98109
New Orleans, LA
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Twin Cities Hospital
Niceville, Florida 32578
2228
mi
from 98109
Niceville, FL
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North Hills Hospital
North Richland Hills, Texas 76180
1660
mi
from 98109
North Richland Hills, TX
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Ocala Regional Medical Center
Ocala, Florida 34480
2488
mi
from 98109
Ocala, FL
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West Marion Community Hospital
Ocala, Florida 34474
2483
mi
from 98109
Ocala, FL
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Ogden Regional Medical Center
5475 South 500 East
Ogden, Utah 84405
678
mi
from 98109
Ogden, UT
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Raulerson Hospital
Okeechobee, Florida 34972
?
mi
from 98109
Okeechobee, FL
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Orange Park Medical Center
Orange Park, Florida 32073
2534
mi
from 98109
Orange Park, FL
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Timpanogos Regional Medical Center
750 West 800 North
Orem, Utah 84057
730
mi
from 98109
Orem, UT
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Menorah Medical Center
5721 W 119th St
Overland Park, Kansas 66209
(913) 498-6000
Menorah Medical Center Menorah Medical Center (MMC), a full-service, acute care hospital located on the...
1508
mi
from 98109
Overland Park, KS
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Overland Park Regional Medical Center
Overland Park, Kansas 66215
1503
mi
from 98109
Overland Park, KS
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Gulf Coast Medical Center
Panama City, Florida 32405
2281
mi
from 98109
Panama City, FL
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Bayshore Medical Center
Pasadena, Texas 77504
1903
mi
from 98109
Pasadena, TX
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Mountain View Hospital - Utah
Payson, Utah 84651
?
mi
from 98109
Payson, UT
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West Florida Hospital
Pensacola, Florida 32514
2200
mi
from 98109
Pensacola, FL
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The Medical Center of Plano
Plano, Texas 75075
1673
mi
from 98109
Plano, TX
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Plantation General Hospital
Plantation, Florida 33317
?
mi
from 98109
Plantation, FL
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Westside Regional Medical Center
Plantation, Florida 33324
2712
mi
from 98109
Plantation, FL
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Fawcett Memorial Hospital
Port Charlotte, Florida 33952
2589
mi
from 98109
Port Charlotte, FL
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St Lucie Medical Center
Port Saint Lucie, Florida 34952
2651
mi
from 98109
Port Saint Lucie, FL
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Portsmouth Regional Hospital
Portsmouth, New Hampshire 03801
2476
mi
from 98109
Portsmouth, NH
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LewisGale Hospital - Pulaski
Pulaski, Virginia 24301
2214
mi
from 98109
Pulaski, VA
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Reston Hospital
Reston, Virginia 20190
2305
mi
from 98109
Reston, VA
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Henrico Doctors' Hospital - Retreat Campus
Richmond, Virginia 23220
?
mi
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Richmond, VA
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