APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO)



Status:Not yet recruiting
Conditions:Renal Impairment / Chronic Kidney Disease, Renal Impairment / Chronic Kidney Disease
Therapuetic Areas:Nephrology / Urology
Healthy:No
Age Range:Any
Updated:2/17/2019
Start Date:March 2019
End Date:September 2023
Contact:Laurie P. Russell, MS
Email:lrussell@wakehealth.edu
Phone:336-713-4292

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The APOLLO study is being done in an attempt to improve outcomes after kidney transplantation
and to improve the safety of living kidney donation based upon variation in the
apolipoprotein L1 gene (APOL1). Genes control what is inherited from a family, such as eye
color or blood type. Variation in APOL1 can cause kidney disease. African Americans,
Afro-Caribbeans, Hispanic Blacks, and Africans are more likely to have the APOL1 gene
variants that cause kidney disease. APOLLO will test DNA from kidney donors and recipients of
kidney transplants for APOL1 to determine effects on kidney transplant-related outcomes.

The National Institutes of Health (NIH)-sponsored collaborative APOL1 Long-term Kidney
Transplantation Outcomes Network (APOLLO) is charged with prospectively assessing the effects
of renal-risk variants (RRVs) in the apolipoprotein L1 gene (APOL1) on outcomes for kidneys
from donors with recent African ancestry and the recipients of their kidneys, after deceased-
and living-donor renal transplantation. For the purposes of APOLLO, recent African ancestry
is defined as individuals with similar genetic make-up to those currently residing in Africa.
APOLLO will also study the impact of APOL1 RRVs on the health of living kidney donors with
recent African ancestry.

Inclusion Criteria for Living Donors:

- Living kidney donors with self-reported recent African ancestry (defined as African
American, Afro-Caribbean, Hispanic black or African) will be eligible for inclusion.

Exclusion Criteria for Living Donors:

- Participants who are unable or unwilling to provide informed consent.

Inclusion Criteria for Recipients:

- Recipients of a kidney transplant from an eligible living or deceased donor with
recent African ancestry.

- Recipients of multi-organ transplants including a kidney plus an additional organ
(i.e. liver, heart, lung, pancreas, etc.) or pediatric en bloc and dual kidney
transplants.

Exclusion Criteria for Recipients:

- Participants who are unable or unwilling to provide informed consent.
We found this trial at
18
sites
1720 2nd Ave S
Birmingham, Alabama 35233
(205) 934-4011 
Principal Investigator: Bruce A. Julian, MD
Phone: 205-996-7733
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
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1648 Pierce Dr NE
Atlanta, Georgia 30322
(404) 727-5640
Principal Investigator: Stephen O. Pastan, MD
Phone: 404-712-1816
Emory University School of Medicine Emory University School of Medicine has 2,359 full- and part-time...
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3400 N Charles St
Baltimore, Maryland 21205
410-516-8000
Principal Investigator: Daniel C. Brennan, MD
Phone: 410-614-6702
Johns Hopkins University The Johns Hopkins University opened in 1876, with the inauguration of its...
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Baltimore, MD
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9500 Euclid Avenue
Cleveland, Ohio 44106
216.444.2200
Principal Investigator: Emilio D. Poggio, MD
Phone: 216-444-3256
Cleveland Clinic Cleveland Clinic is committed to principles as presented in the United Nations Global...
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Durham, North Carolina 27710
(919) 684-8111
Principal Investigator: Rasheed A. Gbadegesin, MD
Phone: 919-681-8730
Duke University Younger than most other prestigious U.S. research universities, Duke University consistently ranks among...
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1211 Medical Center Dr
Nashville, Tennessee 37232
(615) 322-5000
Principal Investigator: Kelly A. Birdwell, MD
Phone: 615-343-1218
Vanderbilt Univ Med Ctr Vanderbilt University Medical Center (VUMC) is a comprehensive healthcare facility dedicated...
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Ann Arbor, Michigan 48109
Principal Investigator: Mona D. Doshi, MD
Phone: 216-444-3256
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655 West Baltimore Street
Baltimore, Maryland 21201
(410) 706-7410
Principal Investigator: Jonathan S. Bromberg, MD
Phone: 410-328-0303
University of Maryland School of Medicine Established in 1807, The School of Medicine is the...
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Boston, Massachusetts 02215
Principal Investigator: Sylvia E. Rosas, MD
Phone: 617-309-4130
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Madison, Wisconsin 53706
(608) 263-2400
Principal Investigator: Brad Astor, PhD
Phone: 608-263-1864
University of Wisconsin-Madison In achievement and prestige, the University of Wisconsin-Madison has long been recognized...
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Miami, Florida 33133
Principal Investigator: Alessia Fornoni, MD, PhD
Phone: 305-355-5315
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New York, New York 10029
Principal Investigator: Barbara Murphy, MD
Phone: 212-241-0255
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New York, New York 10032
Principal Investigator: Sumit Mohan, MD
Phone: 212-305-8392
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New York, New York 10065
Principal Investigator: Darshana M. Dadhania, MD
Phone: 212-746-6112
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3451 Walnut St
Philadelphia, Pennsylvania 19104
1 (215) 898-5000
Principal Investigator: Deirdre L. Sawinski, MD
Phone: 212-305-8392
Univ of Pennsylvania Penn has a long and proud tradition of intellectual rigor and pursuit...
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Saint Louis, Missouri 63104
Principal Investigator: Krista L. Lentine, MD, PhD
Phone: 314-577-8460
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San Francisco, California 94143
Principal Investigator: Chi-yuan Hsu, MD
Phone: 415-476-8695
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Winston-Salem, North Carolina 27157
Principal Investigator: Barry I. Freedman, MD
Phone: 336-716-4246
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