Remifentanil Plus Ketamine for Dynamic Flexible Bronchoscopy
| Status: | Not yet recruiting |
|---|---|
| Conditions: | Pulmonary |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 19 - Any |
| Updated: | 10/21/2018 |
| Start Date: | March 1, 2019 |
| End Date: | December 31, 2019 |
| Contact: | Satya Krishna Ramachandran, MD |
| Email: | skrama@bidmc.harvard.edu |
| Phone: | 617-667-5531 |
Remifentanil Plus Ketamine Versus Midazolam Plus Fentanyl for Dynamic Flexible Bronchoscopy: Randomized Double-blind Clinical Trial
This randomized controlled pilot clinical trial will enroll patients undergoing dynamic
flexible bronchoscopy will be randomized to receive one of the two anesthetic combinations
described above. The study will determine if there is a difference when considering patient
and physician and satisfaction when performing DFB. Also, safety and efficacy of the two
pharmacological combinations (fentanyl + midazolam and remifentanil + ketamine) used will be
evaluated.
flexible bronchoscopy will be randomized to receive one of the two anesthetic combinations
described above. The study will determine if there is a difference when considering patient
and physician and satisfaction when performing DFB. Also, safety and efficacy of the two
pharmacological combinations (fentanyl + midazolam and remifentanil + ketamine) used will be
evaluated.
Inclusion criteria:
- Adult (>18 years-old)
- Undergoing planned flexible bronchoscopy with dynamic maneuvers for Excessive Central
Airway Collapse assessment at Beth Israel Deaconess Medical Center.
Exclusion criteria:
- Patients with any past medical history of disease that would put them at risk of
receiving one of the four proposed medications. This includes, but it's not limited
to, allergies, advanced stage kidney disease, congestive heart failure and
non-controlled hypertension.
- With a known/documented history of opioid abuse at any point during life.
- PO2< 60 mmHg or SO2 <85% on room air during any of the encounters with physicians
between the moment of initial screening and the procedure itself.
- PaCO2 >60 mmHg
- Planned additional procedure(s) requiring general anesthesia after the dynamic
bronchoscopy.
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