Sucrose-sweetened Beverage in African-American and Caucasian Women.

This is a dietary intervention during which participants will consume a SSB daily, with each
meal for two weeks. At the beginning and end of the two-week intervention, participants will
have blood drawn under fasting and postprandial (after a meal) conditions for the measurement
of lipid risk factors associated with cardiovascular disease. Participants will also undergo
an oral glucose tolerance test (OGTT) to assess insulin sensitivity. All sugar-sweetened
beverages will be provided.

Inclusion Criteria:

- BMI 25 - 35 kg/m2

Exclusion Criteria:

- Does not identify as African-American or non-hispanic White

- Glucose intolerance (fasting glucose >100 mg/dl)

- Evidence of liver disorder (AST or ALT >200% upper limit of normal range)

- Evidence of kidney disorder (>2.0mg/dl creatinine)

- Evidence of thyroid disorder (out of normal range)

- Systolic blood pressure consistently over 140mmHg or diastolic blood pressure over
90mmHg

- Triglycerides > 150mg/dl

- LDL-C > 130mg/dl

- Hemoglobin < 8.5 g/dL

- Pregnant or lactating women

- Current, prior (within 12 months), or anticipated use of any hypolipidemic or
anti-diabetic agents PROTOCOL TITLE: The Effects of Sucrose Beverage on
African-American and Caucasian Women (SAAC) Study Page 4 of 18 Revised: November 27,
2013

- Use of thyroid, anti-hypertensive, anti-depressant, weight loss medications or any
other medication which, in the opinion of the investigator, may confound study results

- Use of chronic corticosteroids (everyday use for a month or longer)

- Use of tobacco

- Strenuous exerciser (>3.5 hours/week at a level more vigorous than walking)

- Surgery for weight loss

- Diet exclusions: Food allergies, special dietary restrictions, food allergies, routine
consumption of less than 3 meals/day, routine ingestion of more than 2 sugar-sweetened
beverages or 1 alcoholic beverage/day, unwillingness to consume any food on study menu

- Veins that are assessed by the CCRC R.N.s as being unsuitable for long-term infusions
and multiple blood draws from a catheter

- Any other condition that, in the opinion of the investigators, would put the subject
at risk

- We will exclude individuals from each of the following special populations:

- Adults unable to consent

- Individuals who are not yet adults (infants, children, teenagers < 18 years)

- Pregnant women

- Prisoners