Research Study to Look at How Well Semaglutide is at Lowering Weight When Taken Together With an Intensive Lifestyle Program

This study will look at the change in participant's body weight from the start to the end of
the study. This is to compare the effect on body weight in people taking semaglutide (a new
medicine) and people taking "dummy" medicine. Together with the medicine, the participant
will also be part of an intensive lifestyle program where the participant will have talks
with study staff about healthy food choices, what the participant can do to lose weight and
be more physically active. The participant will either get semaglutide or "dummy" medicine -
which treatment the participant gets is decided by chance. The participant will need to take
1 injection once a week. The study medicine is injected with a thin needle in a skin fold in
the stomach, thigh or upper arm. For the first 2 months the participant will be on a low
calorie diet. The diet is made up of bars, shakes and 1 low calorie pre-prepared meal for
each day. The study will last for about 1.5 years. The participant will have 32 clinic visits
with the study doctor.