Navigated Repetitive Transcranial Magnetic Stimulation in Improving Motor Rehabilitation in Participants With Grade II-IV Brain Tumors

PRIMARY OBJECTIVES:

I. Determine feasibility of conducting 10 sessions of navigated repetitive transcranial
magnetic stimulation (nrTMS) during the post-surgical rehabilitation time period.

SECONDARY OBJECTIVES:

I. Explore the effects of the nrTMS training program on motor recovery. II. Explore changes
in cortical activity: electroencephalographic (EEG) activity including event-related
potentials (ERPs) and motor evoked potentials (MEPs) will be assessed from baseline to end of
treatment (EOT).

OUTLINE:

Between 1-7 days after standard of care surgery, participants undergo 10 nrTMS sessions over
30 minutes each over 3 weeks.

After completion of study, participants are followed up at 3 months.

Inclusion Criteria:

1. patients with brain tumors associated with the motor cortex

2. understand and read English, sign a written informed consent, and be willing to follow
protocol requirements

3. ECOG Performance Status of 0-2

4. motor impairment must be related to the surgical procedure or the tumor itself (in the
opinion of the treating physician)

5. patients who are within 7 days of brain tumor resection associated with the motor
cortex and who have been enrolled in the study prior to their surgical procedure

Exclusion Criteria:

1. Patients who are taking any antipsychotic medications

2. patients who have ever been diagnosed with bipolar disorder or schizophrenia

3. patients with a history of stroke