Dosing of Methadone for Spine Surgery
| Status: | Recruiting |
|---|---|
| Conditions: | Post-Surgical Pain |
| Therapuetic Areas: | Musculoskeletal |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 4/6/2019 |
| Start Date: | March 19, 2019 |
| End Date: | December 2020 |
| Contact: | Judith Wishin, BSN |
| Email: | jwishin@anest.ufl.edu |
| Phone: | 352-665-2765 |
This study compares two methods of dosing methadone for complex spine cases
Patients with spine surgery experience a significant amount of pain that can interfere with
healing, rehabilitation and contribute to morbidity in the post-operative period. This study
will compare post-operative opioid requirement at 24 and 48 hours to determine if methadone
given in small aliquots until respiratory depression can act as a self-control to determine
the correct dose required.
healing, rehabilitation and contribute to morbidity in the post-operative period. This study
will compare post-operative opioid requirement at 24 and 48 hours to determine if methadone
given in small aliquots until respiratory depression can act as a self-control to determine
the correct dose required.
Inclusion Criteria:
- Patients must consent to participate and sign the Institutional Review Board (IRB)
approved informed consent prior to beginning any study specific procedures.
- Undergoing multiple thoracolumbar spine surgery with instrumentation and fusion
Exclusion Criteria:
- History of methadone use
- Morbid obesity with BMI>40 Kg/m2.
- Chronic renal failure with creatinine>2.0 mg/dL
- Liver failure as determined by cirrhosis or history of fulminant hepatic failure
- History of alcohol abuse
- History of drug abuse
- History of myocardial infarction or heart failure.
- Patients with American Society of Anesthesiologists (ASA) status IV or V
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