Liver, Pancreas and Thyroid Function in Burn Patients



Status:Recruiting
Conditions:Other Indications, Endocrine, Gastrointestinal, Gastrointestinal
Therapuetic Areas:Endocrinology, Gastroenterology, Other
Healthy:No
Age Range:Any
Updated:7/27/2018
Start Date:June 25, 2018
End Date:June 30, 2020
Contact:Christian Tapking, MD
Email:chtapkin@utmb.edu
Phone:409 770 6964

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A Prospective Study to Evaluate the Outcome of Liver, Pancreas and Thyroid Function in Severely Burned Patients

The purpose of this study is to determine the extent to which severe burn injuries affect the
morphology and function of liver, pancreas and thyroid. The evaluation of the liver will be
performed non-invasively with liver fibrosis scores based on standard blood parameters and
the measurement of liver stiffness (correlated with liver fibrosis) and controlled
attenuation parameter (CAP, correlated with hepatic steatosis) via transient elastography
(FibroScan©, Echosens SA, Paris, France). The thyroid and the pancreas will be assessed via
ultrasound (GE Medical Systems, Waukesha, USA) and standard blood parameters, respectively.

In this prospective study, the extent to which severe burn injuries affect the morphology and
function of liver, pancreas and thyroid. The evaluation of the liver will be performed
non-invasively with liver fibrosis scores based on standard blood parameters, the
ultrasound-guided measurement of the liver size and the measurement of liver stiffness
(correlated with liver fibrosis) and controlled attenuation parameter (CAP, correlated with
hepatic steatosis) via transient elastography (FibroScan©, Echosens SA, Paris, France). The
thyroid will be assessed by ultrasound and standard blood parameters and the pancreas by
standard blood parameters only, respectively.

The patient will be enrolled during the first days on their admission to the intensive care
burn unit, if they meet the inclusion criteria and no exclusion criteria are met. The first
assessment of liver, pancreas and thyroid function will be performed within the first 48
hours of admission. The same measurements maybe be repeated approximately weekly until
discharge, respectively. Furthermore at any follow-up visit up to 15 years post-burn if the
patient consents to further participate in the study.

Inclusion Criteria:

Patients with partial thickness burns. Only patients who sign an IRB-approved consent (≥18
years old) or assent and have their legal guardian consenting to their participation (6
months - 17 years old) will be included.

- Patient age > 6 months

- Total body surface area (TBSA) burned ≥ 30 %

- Flame, electrical, scald or chemical injury, contact burn

- Toxic epidermal necrolysis (TENS)

Exclusion Criteria:

- Patient < 6 months

- TBSA burned < 30 %
We found this trial at
1
site
301 University Blvd
Galveston, Texas 77555
(409) 772-1011
Phone: 409-770-6964
University of Texas Medical Branch Established in 1891 as the University of Texas Medical Department,...
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Galveston, TX
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