Targeting Sleep in Kids With Autism Spectrum Disorder

Children with ASD and insomnia, and their parent(s) will undergo 8 sessions of CBT-CI-A.
Treatment delivery will be assessed for each session. Treatment receipt will be assessed at
the end of session 3. Treatment enactment will be assessed throughout treatment,
post-treatment, and follow-up. Sleep and secondary outcomes (child daytime behavior, parent
sleep) will be collected at baseline, post-treatment, and 1-month follow-up.

Children (6-12 yrs; n = 30) who meet full DSM (Diagnostic and Statistical Manual) criteria18
for ASD and insomnia will be recruited from an existing clinical registry database.
Eligibility criteria for initial recruitment will include IQ (intelligence quotient) of 75 or
above (to ensure ability to participate in cognitive components of treatment), previous DSM
diagnosis of ASD, and previous evaluation using gold standard diagnostic tools, including the
Autism Diagnostic Observation Schedule (ADOS)27 and/or Autism Diagnostic Interview - Revised
(ADI-R).28 The Thompson Center database currently includes 337 children with ASD ages 6-12
who have completed the ADOS and/or ADIR and have IQ>75. Following initial recruitment,
eligibility for participation will include DSM diagnosis of insomnia. Insomnia will be
diagnosed by study staff using gold standard diagnostic tools, a brief (10 min.) structured
interview, Child Sleep Habits Questionnaire29, and sleep diaries.30 Child will report or
parent will observe sleep latency (time to fall asleep) or wake during the night >30 minutes
that is confirmed by baseline sleep diaries. Dr. Sahota will provide referrals for children
with suspected sleep apnea. Additional criteria will include participation of the child's
parent or legal guardian living in the same home, and parental ability to read and understand
English at the 5th grade level. Given previous experience, size of the database and insomnia
prevalence in ASD, the investigators expect no difficulty recruiting our target sample size.

Treatment will be manualized and individually administered by graduate students trained by
Drs. McCrae and Mazurek. Parent and child will be actively involved in treatment.

CBT-CI-A will use established behavioral sleep strategies.5-7 Treatment will be adapted from
a manualized protocol developed and tested by Dr. McCrae in TD children. Adaptations for
children with ASD will be based on Dr. Mazurek's experience and expertise, practice pathway
recommendations of the ATN, and previously published CBT adaptations for treatment of anxiety
in children with ASD. Adaptations will include increased use of visual supports, greater
opportunities for repetition/practice, incorporation of special interests, and video
modeling.

Inclusion Criteria:

- previous Diagnostic and Statistical Manual of Mental Disorders diagnosis of Autism
Spectrum Disorder, and previous evaluation using gold standard diagnostic tools,
including the Autism Diagnostic Observation Schedule (ADOS)27 and/or Autism Diagnostic
Interview - Revised (ADI-R).

- Who have IQ>75.

- Child will report or parent will observe sleep latency (time to fall asleep) or wake
during the night >30 minutes that is confirmed by baseline sleep diaries.

- Participation of the child's parent or legal guardian living in the same home, and
parental ability to read and understand English at the 5th grade level.

Exclusion Criteria:

- unable to provide informed consent

- unable to implement treatment due to sleep disorder other than insomnia (i.e., sleep
apnea [apnea/hypopnea index, AHI >15], Periodic Limb Movement Disorder (PLMD
[myoclonus arousals per hour >15])

- bipolar or seizure disorder (due to risk of sleep restriction treatment)

- other major psychopathology except depression or anxiety (e.g., suicidal
ideation/intent, psychotic disorders)