Early Diagnosis and Stem Cell Transplantation for Severe Immunodeficiency Diseases



Status:Recruiting
Conditions:HIV / AIDS
Therapuetic Areas:Immunology / Infectious Diseases
Healthy:No
Age Range:Any - 11
Updated:4/2/2016
Start Date:December 2007
End Date:December 2017
Contact:Morris Kletzel, MD
Email:mkletzel@childrensmemorial.org
Phone:773-880-4562

Use our guide to learn which trials are right for you!

The hypothesis of this study is that children with severe primary immunodeficiencies will
benefit from early stem cell transplantation utilizing a reduced intensity conditioning
regimen. This regimen is associated with a low risk of complications and will lead to
correction of the underlying immunological defects.


Inclusion Criteria:

- Must show one of the following diseases:

- SCIDS

- Hyper-IgM

- Wiskott-Aldrich Syndrome

- Chediak-Higashi and Griscelli Syndromes

- X-Linked Lymphoproliferative Diseases

- IPEX Syndrome

- NEMO Syndrome

- other severe immunodeficiency diseases not stated above at the discretion of the
Principal Investigator

- Informed Consent

- Adequate Renal Function

- Adequate Liver Function

- Adequate Cardiac Function

- Adequate Pulmonary Function

- Adequate Performance Statue

- Adequate Venous Access

Exclusion Criteria:

- Patient/Family has not signed informed consent

- Patient does not have a clear diagnosis of a severe immunodeficiency disease

- A suitable donor for the patient cannot be found

- Patient is HIV positive

- Patient has active Hepatitis B

- Patient is pregnant

- Patient is considered unsuitable for transplant at the discretion of the Principal
Investigators or the medical director
We found this trial at
1
site
Chicago, Illinois 60614
?
mi
from
Chicago, IL
Click here to add this to my saved trials