Early Diagnosis and Stem Cell Transplantation for Severe Immunodeficiency Diseases

Conditions:HIV / AIDS
Therapuetic Areas:Immunology / Infectious Diseases
Age Range:Any - 11
Start Date:December 2007
End Date:December 2017
Contact:Morris Kletzel, MD

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The hypothesis of this study is that children with severe primary immunodeficiencies will
benefit from early stem cell transplantation utilizing a reduced intensity conditioning
regimen. This regimen is associated with a low risk of complications and will lead to
correction of the underlying immunological defects.

Inclusion Criteria:

- Must show one of the following diseases:


- Hyper-IgM

- Wiskott-Aldrich Syndrome

- Chediak-Higashi and Griscelli Syndromes

- X-Linked Lymphoproliferative Diseases

- IPEX Syndrome

- NEMO Syndrome

- other severe immunodeficiency diseases not stated above at the discretion of the
Principal Investigator

- Informed Consent

- Adequate Renal Function

- Adequate Liver Function

- Adequate Cardiac Function

- Adequate Pulmonary Function

- Adequate Performance Statue

- Adequate Venous Access

Exclusion Criteria:

- Patient/Family has not signed informed consent

- Patient does not have a clear diagnosis of a severe immunodeficiency disease

- A suitable donor for the patient cannot be found

- Patient is HIV positive

- Patient has active Hepatitis B

- Patient is pregnant

- Patient is considered unsuitable for transplant at the discretion of the Principal
Investigators or the medical director
We found this trial at
Chicago, Illinois 60614
Chicago, IL
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