Caffeine and Neurologic Recovery Following Surgery and General Anesthesia
| Status: | Recruiting |
|---|---|
| Conditions: | Post-Surgical Pain |
| Therapuetic Areas: | Musculoskeletal |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 7/13/2018 |
| Start Date: | July 10, 2018 |
| End Date: | July 11, 2020 |
| Contact: | Phillip Vlisides, MD |
| Email: | pvliside@umich.edu |
| Phone: | (734) 936-4280 |
The ongoing opioid epidemic is a public health crisis, and surgical patients are particularly
vulnerable to opioid-dependency and related risks. Emerging data suggest that caffeine may
reduce pain after surgery. Thus, the purpose of this study is to test whether caffeine
reduces pain and opioid requirements after surgery. The investigators will also test whether
caffeine improves mood and brain function (e.g., learning, memory) after surgery.
vulnerable to opioid-dependency and related risks. Emerging data suggest that caffeine may
reduce pain after surgery. Thus, the purpose of this study is to test whether caffeine
reduces pain and opioid requirements after surgery. The investigators will also test whether
caffeine improves mood and brain function (e.g., learning, memory) after surgery.
Opioid-related deaths have quadrupled in the last 20 years, and nearly half of these deaths
currently involve prescription opioids. Surgical patients often experience moderate-to-severe
pain is common after major surgery, and surgery is associated with a 14-fold increased risk
of opioid dependency compared to non-surgical controls, even after minor surgery.
Furthermore, mood disorders (e.g., depression) are independently associated with persistent
opioid use postoperatively, and signs of postoperative depression are common after major
surgery. Thus, given these risk factors, surgical patients are at particularly high risk for
opioid dependency postoperatively. Interventions that (1) reduce opioid burden, and (2)
improve mood and neuropsychological function may mitigate the risk of postoperative opioid
dependency. Preliminary laboratory and clinical findings demonstrate that caffeine may reduce
pain after surgery, which may translate to lower opioid requirements. The study tests the
hypothesis that intraoperative caffeine administration will improve opioid consumption, pain,
and neuropsychological recovery in patients undergoing surgery. Through validated assessment
measures, the research team will study the effects of caffeine in relation to postoperative
opioid requirements, pain, and neuropsychological (e.g., cognition, depression, anxiety)
trajectory after surgery.
currently involve prescription opioids. Surgical patients often experience moderate-to-severe
pain is common after major surgery, and surgery is associated with a 14-fold increased risk
of opioid dependency compared to non-surgical controls, even after minor surgery.
Furthermore, mood disorders (e.g., depression) are independently associated with persistent
opioid use postoperatively, and signs of postoperative depression are common after major
surgery. Thus, given these risk factors, surgical patients are at particularly high risk for
opioid dependency postoperatively. Interventions that (1) reduce opioid burden, and (2)
improve mood and neuropsychological function may mitigate the risk of postoperative opioid
dependency. Preliminary laboratory and clinical findings demonstrate that caffeine may reduce
pain after surgery, which may translate to lower opioid requirements. The study tests the
hypothesis that intraoperative caffeine administration will improve opioid consumption, pain,
and neuropsychological recovery in patients undergoing surgery. Through validated assessment
measures, the research team will study the effects of caffeine in relation to postoperative
opioid requirements, pain, and neuropsychological (e.g., cognition, depression, anxiety)
trajectory after surgery.
Inclusion Criteria:
- Adult (>/= 18 years old) undergoing non-cardiac, non-neurologic, non-major vascular
surgery requiring general anesthesia
Exclusion Criteria:
- Emergency surgery
- Cognitive impairment precluding capacity for informed consent
- Uncontrolled cardiac arrhythmias
- Seizure disorders
- Preoperative opioid use
- Diabetes
- Liver failure
- Pregnancy
- Breastfeeding
- Severe visual or auditory impairment (may hinder cognitive function testing)
- Patients unable to speak English.
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