Hypofractionated Radiotherapy in Breast Cancer
| Status: | Recruiting |
|---|---|
| Conditions: | Breast Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | Any - 50 |
| Updated: | 7/5/2018 |
| Start Date: | December 2010 |
| End Date: | October 2019 |
| Contact: | Mylin Torres, MD |
| Email: | matorre@emory.edu |
| Phone: | 404-778-3473 |
A Pilot Study of Hypofractionated Simultaneous Integrated Boost Radiotherapy in Stage 0, I and III Breast Cancer Patients
As the number of breast cancer (BrCA) survivors has markedly increased, clinicians are now
seeking to reduce treatment-related toxicities and inconveniences of treatment, namely the
traditional 6 weeks of daily radiation treatment (XRT). Skin thickening, fibrosis, and edema
are some of the most common acute and potentially long-term debilitating toxicities of BrCA
XRT.
The purpose of this study is to learn if three weeks of daily radiation treatment (RT) to the
breast is safe in breast cancer patients who are usually prescribed 6 weeks of daily
radiation after breast surgery (e.g. lumpectomy or mastectomy) as standard of care.
seeking to reduce treatment-related toxicities and inconveniences of treatment, namely the
traditional 6 weeks of daily radiation treatment (XRT). Skin thickening, fibrosis, and edema
are some of the most common acute and potentially long-term debilitating toxicities of BrCA
XRT.
The purpose of this study is to learn if three weeks of daily radiation treatment (RT) to the
breast is safe in breast cancer patients who are usually prescribed 6 weeks of daily
radiation after breast surgery (e.g. lumpectomy or mastectomy) as standard of care.
As the number of breast cancer (BrCA) survivors has markedly increased, clinicians are now
seeking to reduce treatment-related toxicities and inconveniences of treatment, namely the
traditional 6 weeks of daily radiation treatment (XRT). Skin thickening, fibrosis, and edema
are some of the most common acute and potentially long-term debilitating toxicities of BrCA
XRT.
The purpose of this study is to learn if three weeks of daily radiation treatment (RT) to the
breast is safe in breast cancer patients who are usually prescribed 6 weeks of daily
radiation after breast surgery (e.g. lumpectomy or mastectomy) as standard of care.
Investigators seek to assess the rate of cutaneous toxicity, the rates of lymphedema
determined by arm measurements and Grade 3 brachial plexopathy in patients receiving regional
nodal irradiation, as well as local control, quality of life, and fatigue levels.
seeking to reduce treatment-related toxicities and inconveniences of treatment, namely the
traditional 6 weeks of daily radiation treatment (XRT). Skin thickening, fibrosis, and edema
are some of the most common acute and potentially long-term debilitating toxicities of BrCA
XRT.
The purpose of this study is to learn if three weeks of daily radiation treatment (RT) to the
breast is safe in breast cancer patients who are usually prescribed 6 weeks of daily
radiation after breast surgery (e.g. lumpectomy or mastectomy) as standard of care.
Investigators seek to assess the rate of cutaneous toxicity, the rates of lymphedema
determined by arm measurements and Grade 3 brachial plexopathy in patients receiving regional
nodal irradiation, as well as local control, quality of life, and fatigue levels.
Inclusion Criteria:
Participants must have one or more of the following characteristics and be eligible for
breast or chest wall with or without regional nodal radiotherapy:
- Prior Chemotherapy for Breast Cancer
- Greater than 25 cm of breast separation (the largest distance on an axial slice of the
planning CT simulation scan between the entry and exit points of the radiation beam on
the body)
- Non-Caucasian Race
- Less than or equal to 50 years of age
- Requiring regional nodal irradiation without evidence of N3 disease
Exclusion Criteria:
- Males will be excluded
- Women who are pregnant or nursing a child may not take part in this study
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