Efficacy and Safety of Tofacitinib in Subjects With Active Ankylosing Spondylitis (AS)



Status:Recruiting
Conditions:Arthritis, Neurology, Neurology
Therapuetic Areas:Neurology, Rheumatology
Healthy:No
Age Range:18 - Any
Updated:4/6/2019
Start Date:June 7, 2018
End Date:September 2, 2020
Contact:Pfizer CT.gov Call Center
Email:ClinicalTrials.gov_Inquiries@pfizer.com
Phone:1-800-718-1021

Use our guide to learn which trials are right for you!

A PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, STUDY OF THE EFFICACY AND SAFETY OF TOFACITINIB IN SUBJECTS WITH ACTIVE ANKYLOSING SPONDYLITIS (AS)

The purpose of this study is to determine if tofacitinib is safe and effective in subjects
with active ankylosing spondylitis.


Inclusion Criteria:

- Has a diagnosis of Ankylosing Spondylitis (AS) based on the Modified New York Criteria
for AS (1984).

- Must have a radiograph of SI joints (AP Pelvis) documenting diagnosis of AS.

- Has active disease despite nonsteroidal anti-inflammatory drug (NSAID) therapy or
intolerant to NSAIDs.

Exclusion Criteria:

- History of known or suspected complete ankylosis of the spine.

- History of allergies, intolerance or hypersensitivity to lactose or tofacitinib.

- History of any other rheumatic disease.

- Any subject with condition affecting oral drug absorption.
We found this trial at
33
sites
Eagan, Minnesota 55121
?
mi
from
Eagan, MN
Click here to add this to my saved trials
Birmingham, Alabama 35205
?
mi
from
Birmingham, AL
Click here to add this to my saved trials
4641 Main Street
Bridgeport, Connecticut 06606
?
mi
from
Bridgeport, CT
Click here to add this to my saved trials
?
mi
from
Colleyville, TX
Click here to add this to my saved trials
Columbia, Maryland 21046
?
mi
from
Columbia, MD
Click here to add this to my saved trials
?
mi
from
Columbia, SC
Click here to add this to my saved trials
Corpus Christi, Texas 78404
?
mi
from
Corpus Christi, TX
Click here to add this to my saved trials
Covina, California 91723
?
mi
from
Covina, CA
Click here to add this to my saved trials
?
mi
from
Dallas, TX
Click here to add this to my saved trials
Duncansville, Pennsylvania 16635
?
mi
from
Duncansville, PA
Click here to add this to my saved trials
Durham, North Carolina 27704
?
mi
from
Durham, NC
Click here to add this to my saved trials
215 South Hickory Street
Escondido, California 92025
?
mi
from
Escondido, CA
Click here to add this to my saved trials
?
mi
from
Gilbert, AZ
Click here to add this to my saved trials
Houston, Texas 77030
?
mi
from
Houston, TX
Click here to add this to my saved trials
Houston, Texas 77030
?
mi
from
Houston, TX
Click here to add this to my saved trials
Houston, Texas 77030
?
mi
from
Houston, TX
Click here to add this to my saved trials
?
mi
from
Huntsville, AL
Click here to add this to my saved trials
Lansing, Michigan 48917
?
mi
from
Lansing, MI
Click here to add this to my saved trials
Lexington, Kentucky 40504
?
mi
from
Lexington, KY
Click here to add this to my saved trials
Maroochydore, Queensland
?
mi
from
Maroochydore,
Click here to add this to my saved trials
Mesquite, Texas 75150
?
mi
from
Mesquite, TX
Click here to add this to my saved trials
Miami, Florida 33144
?
mi
from
Miami, FL
Click here to add this to my saved trials
Middleburg Heights, Ohio 44130
?
mi
from
Middleburg Heights, OH
Click here to add this to my saved trials
Ormond Beach, Florida 32174
?
mi
from
Ormond Beach, FL
Click here to add this to my saved trials
?
mi
from
Plano, TX
Click here to add this to my saved trials
505 Parnassus Ave
San Francisco, California 94143
(415) 476-1000
University of California, San Francisco Medical Center UCSF Medical Center is recognized throughout the world...
?
mi
from
San Francisco, CA
Click here to add this to my saved trials
Spokane, Washington 99204
?
mi
from
Spokane, WA
Click here to add this to my saved trials
Stamford, Connecticut 06095
?
mi
from
Stamford, CT
Click here to add this to my saved trials
Stamford, Connecticut 06902
?
mi
from
Stamford, CT
Click here to add this to my saved trials
?
mi
from
Summerville, SC
Click here to add this to my saved trials
6707 Sterling Ridge Drive
The Woodlands, Texas 77382
?
mi
from
The Woodlands, TX
Click here to add this to my saved trials
Tustin, California 92780
?
mi
from
Tustin, CA
Click here to add this to my saved trials
?
mi
from
Wheaton, MD
Click here to add this to my saved trials