Effects of Acute Dietary Sodium on Cerebrovascular Reactivity and Blood Pressure Reactivity
| Status: | Recruiting |
|---|---|
| Conditions: | High Blood Pressure (Hypertension) |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - 45 |
| Updated: | 6/22/2018 |
| Start Date: | May 1, 2018 |
| End Date: | July 1, 2020 |
| Contact: | William B Farquhar, PhD |
| Email: | wbf@udel.edu |
| Phone: | 302-831-6178 |
Americans eat more salt than is recommended by the American Heart Association. This is
important because consuming a high-salt diet is associated with an increased risk of
cardiovascular events, like strokes and heart attacks. In fact, consuming one high-salt meal
temporarily reduces blood vessel function and it is not uncommon for Americans to consume
high-salt meals. Therefore, our laboratory is interested in determining if a single high-salt
meal affects 1) brain blood vessel function at rest and 2) blood pressure responses during
exercise.
important because consuming a high-salt diet is associated with an increased risk of
cardiovascular events, like strokes and heart attacks. In fact, consuming one high-salt meal
temporarily reduces blood vessel function and it is not uncommon for Americans to consume
high-salt meals. Therefore, our laboratory is interested in determining if a single high-salt
meal affects 1) brain blood vessel function at rest and 2) blood pressure responses during
exercise.
Excess dietary salt increases the risk of cardiovascular events like strokes and heart
attacks, independent of resting blood pressure. Recent data found that consuming one
high-salt meal temporarily reduces endothelial function in the periphery. This decrease in
endothelial function can lead to an exaggerated blood pressure response during exercise and
may also attenuate cerebrovascular reactivity at rest. This is essential, because an
exaggerated cardiovascular response to exercise and a decrease in brain blood vessel function
at rest are risk factors for future cardiovascular events. The long-term goal is to determine
how dietary salt adversely affects BP and cerebrovascular regulation. The objective of this
proposal is to evaluate the impact of an acute dietary salt meal on BP response during
exercise and cerebrovascular reactivity at rest. The investigators have 2 specific aims: 1)
Aim 1 will test the hypothesis that high dietary salt will reduce cerebrovascular reactivity,
2) Aim 2 will test the hypothesis that high dietary salt will augment blood pressure
reactivity during exercise. The findings of this project will shed light on how acute dietary
salt affects the risk of cardiovascular events during a bout of exercise and long-term risk
for cardiovascular disease and stroke.
attacks, independent of resting blood pressure. Recent data found that consuming one
high-salt meal temporarily reduces endothelial function in the periphery. This decrease in
endothelial function can lead to an exaggerated blood pressure response during exercise and
may also attenuate cerebrovascular reactivity at rest. This is essential, because an
exaggerated cardiovascular response to exercise and a decrease in brain blood vessel function
at rest are risk factors for future cardiovascular events. The long-term goal is to determine
how dietary salt adversely affects BP and cerebrovascular regulation. The objective of this
proposal is to evaluate the impact of an acute dietary salt meal on BP response during
exercise and cerebrovascular reactivity at rest. The investigators have 2 specific aims: 1)
Aim 1 will test the hypothesis that high dietary salt will reduce cerebrovascular reactivity,
2) Aim 2 will test the hypothesis that high dietary salt will augment blood pressure
reactivity during exercise. The findings of this project will shed light on how acute dietary
salt affects the risk of cardiovascular events during a bout of exercise and long-term risk
for cardiovascular disease and stroke.
Inclusion Criteria:
- normal blood pressure
- males, females, minorities
Exclusion Criteria:
- high blood pressure
- body mass index (BMI > 30 kg/m2)
- smokers or nicotine users
- those who are pregnant or planning to become pregnant
- allergy to the tomato soup
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