A Trial of Hu5F9-G4 With Avelumab in Ovarian Cancer



Status:Recruiting
Conditions:Ovarian Cancer, Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:2/6/2019
Start Date:May 24, 2018
End Date:May 2023
Contact:Gani Chico, MD
Email:info@fortyseveninc.com
Phone:(650) 352-4150

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A Phase 1b Trial of Hu5F9-G4 in Combination With Avelumab in Solid Tumor Patients and Checkpoint Inhibitor Naïve Ovarian Cancer Patients Who Progress Within 6 Months of Prior Platinum Chemotherapy

This is an open label, multicenter, Phase 1b trial investigating the combination of Hu5F9 G4
and avelumab in patients with solid tumors and ovarian cancer.


Inclusion Criteria:

- Safety Run-in: Pathologically confirmed advanced solid tumors.

- Ovarian Cancer Expansion: Histologically or cytologically confirmed, epithelial
ovarian, fallopian tube, or peritoneal cancer.

- Ovarian Cancer Expansion: Checkpoint inhibitor naïve patients.

- Ovarian Cancer Expansion: Willing to consent to 1 mandatory pre treatment and 1
on-treatment tumor biopsy.

- Adequate performance status. Adequate hematological, liver, and kidney functions.

- Availability of pre-treatment tumor tisse to evaulate PD-L1 expression.

Exclusion Criteria:

- Patients with symptomatic or untreated central nervous system (CNS) metastases.

- Prior treatment with CD47 or SIRPα targeting agents.

- Known active or chronic hepatitis B or C infection or human immunodeficiency virus
(HIV).

- RBC transfusion dependence.

- Prior organ transplantation requiring immunosuppression or active autoimmune disease.

- Significant medical diseases and/or history of uncontrolled intercurrent illness or
other serious medical condition.

- Pregnancy or active breast feeding.
We found this trial at
6
sites
Dallas, Texas 75390
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5801 South Ellis Avenue
Chicago, Illinois 60637
 773.702.1234
University of Chicago One of the world's premier academic and research institutions, the University of...
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825 Eastlake Ave E
Seattle, Washington 98109
(206) 288-7222
Seattle Cancer Care Alliance Seattle Cancer Care Alliance (SCCA) is a cancer treatment center that...
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Grand Rapids, Michigan 49503
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Grand Rapids, MI
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1100 N. Lindsay
Oklahoma City, Oklahoma 73104
(405) 271-4000
University of Oklahoma The OU Health Sciences Center is composed of seven health-related colleges located...
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Oklahoma City, OK
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San Antonio, TX
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