3M Cavilon Advanced Skin Protectant for the Prophylaxis of Radiation Dermatitis

Inclusion Criteria:

- Age ≥ 18years.

- Patient has initial or recurrent disease

- Undergoing external beam radiotherapy at the Mayo Clinic Rochester campus Note:
Patients who are undergoing concurrent chemotherapy are eligible

- Ability to complete questionnaire(s) by themselves or with assistance

- Provide informed written consent

- Willing to consent for photography of radiation field

- Available to return to Mayo Clinic in within 1 week post treatment for assessment (+/-
7 days).

- At risk for developing ≥ grade 2 dermatitis radiation as determined by treating
Radiation Oncology clinician

- Biologic effective dose of >42 Gy10 as calculated using the web site EQD2.com.

Exclusion Criteria:

- Unable to provide informed consent

- Patients with active rash, pre-existing dermatitis, lupus or scleroderma within the
treatment area that may make skin assessment for the study difficult

- Known history of developing an allergic reaction after using a product containing
cyanoacrylate or acrylates

- Subject has a medical condition that in the opinion of the investigator should exclude
him/her from participating in the study

- Subject has been enrolled in an investigational study where product was applied to the
proposed study site within 30 days of the screening visit

- The skin area affected by radiation requires treatment with a concomitant medication
or product (if applicable)