The Epigenetics of Exercise and Physical Activity in COPD
| Status: | Enrolling by invitation |
|---|---|
| Conditions: | Chronic Obstructive Pulmonary Disease |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 40 - Any |
| Updated: | 6/1/2018 |
| Start Date: | March 1, 2018 |
| End Date: | June 30, 2021 |
This study seeks to examine genome-wide DNA methylation patterns associated with physical
activity and exercise capacity from peripheral blood collected from participants with chronic
obstructive pulmonary disease (COPD) before and after participation in a structured 9-week
outpatient pulmonary rehabilitation program.
activity and exercise capacity from peripheral blood collected from participants with chronic
obstructive pulmonary disease (COPD) before and after participation in a structured 9-week
outpatient pulmonary rehabilitation program.
Individuals who are referred to pulmonary rehabilitation IN THE COURSE OF THEIR USUAL
CLINICAL CARE will be invited to participate in this observational study. Participants who
enroll in the study will undergo two in-person visits, once before initiating pulmonary
rehabilitation classes and once at the conclusion of pulmonary rehabilitation classes.
Participation in this study will not alter the course of the participants' usual clinical
care.
CLINICAL CARE will be invited to participate in this observational study. Participants who
enroll in the study will undergo two in-person visits, once before initiating pulmonary
rehabilitation classes and once at the conclusion of pulmonary rehabilitation classes.
Participation in this study will not alter the course of the participants' usual clinical
care.
Inclusion Criteria:
- Age >40 years
- Diagnosis of COPD (defined as an FEV1/FVC<0.7 or evidence of emphysema on
radiologist's read of a chest CT obtained in the course of patient's usual care)
- Referral to and participation in the VA Boston Pulmonary Rehabilitation program
Exclusion Criteria:
- Active or unstable cardiac disease
- Inability to ambulate > 1 block
- Recent acute exacerbation of COPD (defined as new or increased dose of systemic
steroids and/or antibiotics for pulmonary indications)
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