The Epigenetics of Exercise and Physical Activity in COPD

Status:Enrolling by invitation
Conditions:Chronic Obstructive Pulmonary Disease
Therapuetic Areas:Pulmonary / Respiratory Diseases
Age Range:40 - Any
Start Date:March 1, 2018
End Date:June 30, 2021

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This study seeks to examine genome-wide DNA methylation patterns associated with physical
activity and exercise capacity from peripheral blood collected from participants with chronic
obstructive pulmonary disease (COPD) before and after participation in a structured 9-week
outpatient pulmonary rehabilitation program.

Individuals who are referred to pulmonary rehabilitation IN THE COURSE OF THEIR USUAL
CLINICAL CARE will be invited to participate in this observational study. Participants who
enroll in the study will undergo two in-person visits, once before initiating pulmonary
rehabilitation classes and once at the conclusion of pulmonary rehabilitation classes.
Participation in this study will not alter the course of the participants' usual clinical

Inclusion Criteria:

- Age >40 years

- Diagnosis of COPD (defined as an FEV1/FVC<0.7 or evidence of emphysema on
radiologist's read of a chest CT obtained in the course of patient's usual care)

- Referral to and participation in the VA Boston Pulmonary Rehabilitation program

Exclusion Criteria:

- Active or unstable cardiac disease

- Inability to ambulate > 1 block

- Recent acute exacerbation of COPD (defined as new or increased dose of systemic
steroids and/or antibiotics for pulmonary indications)
We found this trial at
Boston, Massachusetts 02130
Boston, MA
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