Measurement and Training of Dual-Task of Gait in Persons With Multiple Sclerosis

A total target sample size of 40 adults with MS and 40 adults without MS will be recruited.
The 40 adults without MS will undergo the two baseline testing sessions only for the first
phase of the study. 20 of those individuals with MS will be randomly selected to undergo the
intervention phase of the study.

The research design will include two groups, the intervention and control group. Both groups
will undergo a screening process, two baseline testing sessions, and be randomly assigned to
one of the two groups. The duration of the study is 6 weeks in length for a total of 18
training sessions. The intervention group participants will undergo gait training with a
specific concomitant cognitive task (dual-task) for a total walking time of 20 minutes and
with rest breaks the total session time is ~60 minutes with a physical therapist. The control
group will undergo gait training, but without the cognitive task. Feedback from the therapist
will be provided to each participant concerning gait mechanics and ways to improve gait
regardless of group membership.

Outcome measures data will be collected twice at baseline, once at mid-intervention, once at
post-intervention, and once at one-month follow-up.

Inclusion Criteria:

- Ability walk independently with or without an assistive device

- Independent and community-dwelling

- No history or presence of other clinically significant musculoskeletal,
cardiovascular, respiratory, or neurologic disease.

- Definite diagnosis of MS [Expanded Disability Status Scale (EDSS) ≤6.5]

- Relapse free for the past 30 days and not currently receiving or will receive any
rehabilitation services during the study.

Exclusion Criteria:

- Participants experiencing a true relapse or exacerbation of their symptoms (>24 hours
duration in the absence infection or fever, or and ambient increase in body temperature)
during the study will be excluded from the study.