Implementing Genomics in Practice (IGNITE): CYP2D6 Genotype-Guided Pain Management in Patients Undergoing Arthroplasty Surgery



Status:Recruiting
Conditions:Post-Surgical Pain
Therapuetic Areas:Musculoskeletal
Healthy:No
Age Range:18 - 100
Updated:3/17/2019
Start Date:June 7, 2018
End Date:May 2019
Contact:Ben Burkley
Email:burkley@cop.ufl.edu
Phone:352-273-5283

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This will be a randomized, open-labeled pilot pragmatic clinical trial. Patients undergoing
arthroplasty surgery will be recruited for CYP2D6 pharmacogenetic testing from UF Health
Gainesville and the Villages Orthopedic clinics to manage post-surgical pain. Patient will be
randomized to either usual care of genotype-guided care.


Inclusion Criteria:

- Scheduled to undergo total joint arthroplasty at area hospital

- Primary unilateral total hip or knee arthroplasty scheduled within approximately 6
months of the initial evaluation clinic visit

Exclusion Criteria:

- Patients scheduled to undergo a revision or bilateral procedure

- Receiving chronic opioid therapy, defined as use of opioids on most days for > 3 month

- Allergy to opioids will be excluded.
We found this trial at
3
sites
Gainesville, Florida 32611
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2033 Mowry Road
Gainesville, Florida 32610
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Summerfield, Florida 34491
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Summerfield, FL
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