An Investigational Study of Immunotherapy Combinations in Participants With Solid Cancers That Are Advanced or Have Spread



Status:Recruiting
Conditions:Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:3/15/2019
Start Date:May 25, 2018
End Date:May 16, 2022
Contact:Recruiting sites have contact information. Please contact the sites directly. If there is no contact information,
Email:Clinical.Trials@bms.com
Phone:please email:

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A Phase 1/2 Study of Relatlimab (Anti-LAG-3 Monoclonal Antibody) Administered in Combination With Both Nivolumab (Anti-PD-1 Monoclonal Antibody) and BMS-986205 (IDO1 Inhibitor) or in Combination With Both Nivolumab and Ipilimumab (Anti-CTLA-4 Monoclonal Antibody) in Advanced Malignant Tumors

The purpose of this study is to investigate safety and anti-tumor activity of relatlimab
combination therapy in solid cancers that are advanced or have spread


For more information regarding Bristol-Myers Squibb Clinical Trial participation, please
visit www.BMSStudyConnect.com

Inclusion Criteria:

- Histologic or cytologic confirmation of an incurable solid malignancy that is advanced
(metastatic and/or unresectable), with measurable disease per RECIST v1.1

- Available tumor tissue for biomarker analysis

- Eastern Cooperative Oncology Group Performance Status (ECOG) status of 0 or 1

Exclusion Criteria:

- Participants with known or suspected uncontrolled CNS metastases or with the CNS as
the only site of active disease

- Participants with a history of interstitial lung disease (ILD) / pneumonitis

- Prior malignancy active within the previous 3 years except for locally curable cancers
that have been cured, such as basal or squamous cell skin cancer

Other protocol defined inclusion/exclusion criteria could apply
We found this trial at
7
sites
Germantown, Tennessee 38138
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Germantown, TN
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Baltimore, Maryland 21231
410-955-6190
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins The name Johns Hopkins has become synonymous...
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Baltimore, MD
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Aurora, Colorado 80045
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Aurora, CO
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1500 East Duarte Road
Duarte, California 91010
626-256-HOPE (4673)
City of Hope National Medical Center City of Hope is dedicated to making a difference...
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Duarte, CA
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North Sydney, New South Wales 2065
Phone: +61299117200
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North Sydney,
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660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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Saint Louis, MO
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Seattle, Washington 98109
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Seattle, WA
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