United for Health: Type 2 Diabetes Prevention in Latino Teens

This study is a comparative effectiveness pilot trial to evaluate the feasibility and
acceptability of a 12-session community-delivered, family-based type 2 diabetes preventative
lifestyle intervention, delivered over 6 weeks, that includes mindfulness-based stress
reduction training - "Salud sin Barreras" (meaning, "Health without Barriers") - in up to 50
Hispanic/Latino adolescents who are at-risk for developing type 2 diabetes. We also will
estimate the effectiveness of Salud sin Barreras for lowering perceived stress and improving
insulin resistance as compared to a time-matched lifestyle-only intervention, the "La Vida
Saludable" (meaning, the Healthy Living Program; HeLP) in Hispanic/Latino adolescents at-risk
for type 2 diabetes. In addition, we will estimate the impact of the Salud sin Barreras
program, relative to HeLP, on the secondary outcomes of mindfulness, depressive symptoms,
disinhibited eating behavior, sleep quality, physical activity, cortisol, and perceived
impact of discrimination.

Inclusion Criteria:

- Age 12-15 years

- Identify as Hispanic/Latino

- English speaking

- At-risk for T2D by virtue of current BMI ≥ 85th percentile for age and sex by CDC 2000
standards and ≥ 1 first or second degree biological relative with T2D, prediabetes, or
gestational diabetes

- Currently a Salud Family Health Center patient or willing to become a patient of Salud
Family Health Center (required to complete medical assessments at Salud)

Exclusion Criteria:

- Major medical problem, including type 1 diabetes or T2D

- Reported psychiatric disorder that would impede compliance in the opinion of the
investigators

- Started use of medication affecting mood or body weight, such as stimulants or
anti-depressants within the past 3 months

- Any medical issues that could be acutely worsened by exercise such as severe or
uncontrolled asthma or musculoskeletal problems

- Self-reported pregnancy in girls