Ascorbic Acid Levels in MDS, AML, and CMML Patients



Status:Recruiting
Conditions:Blood Cancer, Blood Cancer, Blood Cancer, Blood Cancer, Hematology
Therapuetic Areas:Hematology, Oncology
Healthy:No
Age Range:18 - Any
Updated:5/18/2018
Start Date:November 1, 2017
End Date:October 31, 2018
Contact:Dan Rogers, CCRC, CIP
Email:dan.rogers@vai.org
Phone:616-234-5457

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Collection of Peripheral Blood From Patients With Myelodysplastic Syndrome, Acute Myeloid Leukemia, or Chronic Myelomonocytic Leukemia for Measuring Baseline Ascorbic Acid Levels and Future Epigenetic Cancer Research

This study is a non-interventional, specimen collection translational study to evaluate
vitamin C levels in the peripheral blood of Acute Myeloid Leukemia (AML), Myelodysplastic
Syndrome (MDS), or Chronic Myelomonocytic Leukemia (CMML) patients.

Our collaborators published that hematological cancer patients with myelodysplastic syndrome
(MDS) or acute myeloid leukemia (AML) often exhibit severe vitamin C deficiency. Their study
analyzed specimens from a cohort of patients in Copenhagen. We aim to determine if those
results are conserved in another population/geographical location.

Inclusion Criteria:

- Patients actively receiving treatment for acute myeloid leukemia (AML),
myelodysplastic syndrome (MDS), or chronic myelomonocytic leukemia (CMML).

- Patients diagnosed with AML, MDS, or CMML and are treatment naïve.

- Patients who are 18 years old or older.

Exclusion Criteria:

- Patients deemed as too ill to participate as determined by the clinical investigator.

- Non-English speaking patients

- Patients unable to provide informed consent.
We found this trial at
2
sites
5950 Metro Way
Wyoming, Michigan 49519
Principal Investigator: Michael Zakem, DO
Phone: 616-252-5127
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Grand Rapids, Michigan 49503
Principal Investigator: Brett Brinker, MD
Phone: 616-954-5550
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Grand Rapids, MI
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