Controlled Clinical Trial of Supplemental Oxygen for the Prevention of Post-Cesarean Infectious Morbidity
| Status: | Recruiting |
|---|---|
| Conditions: | Hospital, Women's Studies |
| Therapuetic Areas: | Other, Reproductive |
| Healthy: | No |
| Age Range: | 12 - 50 |
| Updated: | 4/2/2016 |
| Start Date: | February 2008 |
| Contact: | David Stamilio, M.D., M.S.C.E. |
| Email: | stamiliod@wudosis.wustl.edu |
| Phone: | (314) 747-6788 |
Previous studies have demonstrated that patients who undergo surgery while they under
general anesthesia have fewer wound infections if they receive higher concentrations of
oxygen but this has never been studied in women who are undergoing cesarean section. We plan
to randomize women who are undergoing cesarean to receive either standard of care oxygen
flow through a nasal cannula during their cesarean section only or a higher concentration of
oxygen than they would typically receive through a face mask. Women will receive this
therapy during their cesarean and for 2 hours afterwards. We will follow them after their
surgery for evidence of infection either in their wound or their uterus.
general anesthesia have fewer wound infections if they receive higher concentrations of
oxygen but this has never been studied in women who are undergoing cesarean section. We plan
to randomize women who are undergoing cesarean to receive either standard of care oxygen
flow through a nasal cannula during their cesarean section only or a higher concentration of
oxygen than they would typically receive through a face mask. Women will receive this
therapy during their cesarean and for 2 hours afterwards. We will follow them after their
surgery for evidence of infection either in their wound or their uterus.
Inclusion Criteria:
- Pregnant patients undergoing a scheduled or unscheduled cesarean section with
regional anesthesia
Exclusion Criteria:
- Urgent fetal or maternal indications for cesarean section precluding informed consent
- Evidence of extrauterine infection
- HIV infection
- Chronic steroid or other immunosuppressant use
- Patients undergoing general anesthesia
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