Repeated High-dose Inhaled Corticosteroids for Asthma

Inclusion criteria:

- Physician diagnosis of asthma.

- Age ≥18 years and ≤50 years

- Evidence of airflow obstruction as measured by spirometry and flow-volume loop per
American Thoracic Society guidelines.

- Treatment for asthma with:

- daily inhaled corticosteroids and long-acting beta2-agonists, AND

- as-needed use of a short-acting beta2-agonist

Exclusion criteria:

- History of >10 pack-year tobacco use

- Other pulmonary or cardiac diagnosis that is actively being treated

- History of adverse events or allergy to fluticasone

- Systemic corticosteroid therapy within 7 days of study visit

- Inability to obtain written informed consent