Safety/Efficacy Study of Retigabine vs. Placebo in Post-Herpetic Neuralgia (PHN)



Status:Completed
Conditions:Postherpatic Neuralgia
Therapuetic Areas:Neurology
Healthy:No
Age Range:18 - 85
Updated:5/10/2018
Start Date:October 2007
End Date:December 2009

Use our guide to learn which trials are right for you!

A Randomized, Double-Blind, Placebo-Controlled, Phase 2a Proof-of-Concept Study to Evaluate the Efficacy of Maximally Tolerated Doses of Retigabine vs. Placebo in Reducing the Pain Associated With Post-Herpetic Neuralgia

The purpose of the study is to evaluate the efficacy of retigabine vs. placebo in reducing
pain associated with post-herpetic neuralgia.

This is a Phase 2a proof of concept study evaluating the safety/efficacy of retigabine vs.
placebo in patients with post-herpetic neuralgia. After screening, patients will enter a
maximum 6 week titration period followed by a 4 week maintenance period and a 3 week taper
phase.

Inclusion Criteria:

- Ability to provide informed consent

- Male or female subjects

- 18-85 years of age

- PHN for more than 6 months after the healing of herpes zoster skin rash

- Has a pain score at screening and randomization that qualifies

Exclusion Criteria:

- Other significant pain that may potentially confound PHN pain assessment

- Previous neurolytic or neurosurgical therapy for PHN

- Subject has evidence of a progressive central nervous system (CNS) disease (e.g. CNS
lupus, tumors, multiple sclerosis, Alzheimer's), lesion, or encephalopathy

- Significant psychiatric or neuropsychiatric disorders including but not limited to
severe depression, bipolar disorder or schizophrenia spectrum disorder, history of
suicide attempt, or recent history of suicidal ideation

- Has clinically significant abnormalities on physical examination, vital signs, ECG, or
laboratory tests at the screening visit
We found this trial at
40
sites
?
mi
from
Bridgeville, PA
Click here to add this to my saved trials
?
mi
from
Allentown, PA
Click here to add this to my saved trials
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
?
mi
from
Austin, TX
Click here to add this to my saved trials
?
mi
from
Bay City, MI
Click here to add this to my saved trials
?
mi
from
Birmingham, AL
Click here to add this to my saved trials
Charleston, South Carolina 29412
?
mi
from
Charleston, SC
Click here to add this to my saved trials
?
mi
from
Cleveland, OH
Click here to add this to my saved trials
?
mi
from
Detroit, MI
Click here to add this to my saved trials
?
mi
from
Evansville, IN
Click here to add this to my saved trials
?
mi
from
Fargo, ND
Click here to add this to my saved trials
?
mi
from
Garden Grove, CA
Click here to add this to my saved trials
?
mi
from
Hattiesburg, MS
Click here to add this to my saved trials
?
mi
from
La Jolla, CA
Click here to add this to my saved trials
?
mi
from
Lexington, KY
Click here to add this to my saved trials
Little River, South Carolina 29566
?
mi
from
Little River, SC
Click here to add this to my saved trials
?
mi
from
Little Rock, AR
Click here to add this to my saved trials
?
mi
from
Mesa, AZ
Click here to add this to my saved trials
?
mi
from
Midvale, UT
Click here to add this to my saved trials
?
mi
from
Mogadore, OH
Click here to add this to my saved trials
?
mi
from
Nashville, TN
Click here to add this to my saved trials
?
mi
from
New York, NY
Click here to add this to my saved trials
North Myrtle Beach, South Carolina 29582
?
mi
from
North Myrtle Beach, SC
Click here to add this to my saved trials
?
mi
from
Orlando, FL
Click here to add this to my saved trials
?
mi
from
Overland Park, KS
Click here to add this to my saved trials
?
mi
from
Port Elizabeth,
Click here to add this to my saved trials
?
mi
from
Raleigh, NC
Click here to add this to my saved trials
?
mi
from
Saint Louis, MO
Click here to add this to my saved trials
?
mi
from
San Antonio, TX
Click here to add this to my saved trials
?
mi
from
San Diego, CA
Click here to add this to my saved trials
?
mi
from
Sarasota, FL
Click here to add this to my saved trials
?
mi
from
Shreveport, LA
Click here to add this to my saved trials
?
mi
from
Sugar Land, TX
Click here to add this to my saved trials
Tabor City, North Carolina 28463
?
mi
from
Tabor City, NC
Click here to add this to my saved trials
?
mi
from
Tampa, FL
Click here to add this to my saved trials
?
mi
from
Toms River, NJ
Click here to add this to my saved trials
?
mi
from
Tucson, AZ
Click here to add this to my saved trials
?
mi
from
West Palm Beach, FL
Click here to add this to my saved trials
Westlake Village, California 91361
?
mi
from
Westlake Village, CA
Click here to add this to my saved trials
?
mi
from
Winston-Salem, NC
Click here to add this to my saved trials