Characterizing the Synergistic Effects of Physical and Cognitive Training on Attention and Working Memory



Status:Recruiting
Healthy:No
Age Range:55 - 80
Updated:1/17/2019
Start Date:January 2017
End Date:December 2019
Contact:Sierra Niblett
Email:Participate.Neuroscape@ucsf.edu

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The primary goal of this project is to evidence potential synergistic benefits on cognitive
control processes using a video game ("Body-Brain Trainer", or BBT) that integrates cognitive
and physical challenges in a complimentary fashion. Healthy adults will be recruited for a
longitudinal experiment and randomly assigned to one of four study groups to mechanistically
tease apart the possible presence of any synergistic effects on cognitive abilities through
the combination of cognitive & physical challenges.

Cognitive control functions (e.g. attention, working memory, goal-management) dictate our
ability to learn and accomplish selected behavioral goals, with deficiencies in these
processes found in a range of mental illnesses. The primary goal of this project is to
evidence potential synergistic benefits on cognitive control processes using a video game
("Body-Brain Trainer", or BBT) that integrates cognitive and physical challenges in a
complimentary fashion. Healthy adults will be recruited for a longitudinal experiment and
randomly assigned to one of four study groups: 1) BBT, 2) "Brain Training" (BBT played with a
gamepad controller), 3) "Body Training" (BBT without any cognitive demands), and 4) an
expectancy matched placebo control group. Individuals will engage in eight weeks of training
within our Neuroscape Laboratory, with pre- and post-training assessments evaluating
physical, cognitive, and neural measures. The completion of this project will result in a
more sophisticated understanding of how the integration of cognitive and physical training
potentially impacts cognitive control processes, setting the stage for more effective
interventions for mental illness and learning-related impairments.

Inclusion Criteria:

- Can walk briskly for at least 15 minutes continuously without stopping

- Can stand up from a chair without using your hands

- Available to come 3x/week to our UCSF Mission Bay laboratory for 8 weeks

- Willing and able to undergo MRI, EEG procedures

- English fluency

Exclusion Criteria:

- cardiac problems

- bypass surgery

- pacemaker or heart valve replacement

- stroke

- respiratory conditions

- head trauma with loss of consciousness for less than a few minutes

- severe head trauma with loss of consciousness for more than a few minutes

- high/low blood pressure

- kidney failure

- electroconvulsive therapy (ECT)

- seizures

- implanted electrodes

- cancer/chemotherapy/radiation

- diabetes

- irritable bowel syndrome

- back problems

- claustrophobia

- Having been diagnosed with a psychiatric or neurological disorder

- Use of an assistive device (e.g., cane or walker) at any time to assist with
ambulation

- Joint problems causing significant pain upon movement

- Heart Disease or Cardiovascular Disease

- Respiratory Disease (Lung Disease)
We found this trial at
1
site
675 Nelson Rising Lane
San Francisco, California 94158
?
mi
from
San Francisco, CA
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