Decision-making Impairments in OCD: An Integrated Behavioral Economics Model



Status:Recruiting
Conditions:Psychiatric
Therapuetic Areas:Psychiatry / Psychology
Healthy:No
Age Range:18 - Any
Updated:5/9/2018
Start Date:May 3, 2018
End Date:August 30, 2019
Contact:Ryan J Jacoby, Ph.D.
Email:rjjacoby@mgh.harvard.edu
Phone:617-724-4167

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The investigators are examining whether conditions of ambiguity during decision-making may
prime intolerance of uncertainty beliefs (i.e., difficulties coping with ambiguity,
unpredictability, and the future) and lead to impaired performance when individuals with
obsessive-compulsive disorder (OCD) are making uncertain decisions compared to
non-psychiatric controls.

The primary aims of this study are to examine the extent to which individuals with OCD avoid
decisions that involve ambiguity through the use of self-report and behavioral measures.
Specifically, the investigators will examine how individuals with OCD minimize risk at the
expense of monetary profit under conditions of ambiguity (relative to risky but unambiguous
options) compared to non-psychiatric controls utilizing a series of judgment and
decision-making (JDM) tasks. The investigators will also explore two different strategic
responses to ambiguity: information gathering and escape/avoidance.

Inclusion Criteria:

- Adults (age 18+)

- Meet DSM-5 criteria for principal OCD (OCD group) or no current DSM-5 diagnosis (NPC
group).

- Sufficient fluency of English to understand study procedures and questionnaires

- Ability to provide informed consent.

- Comfortable and capable of using a computer to complete computer-based decision-making
tasks.

Exclusion Criteria:

- Color-blindness (which prevents completion of certain tasks)

- Acute psychosis, bipolar disorder, substance use disorder, or suicidality. All other
diagnostic comorbidities will be permitted to foster the accrual of a clinically
relevant sample.

- Serious neurological disorder or impairment (e.g., brain damage, blindness), attention
deficit hyperactivity disorder (ADHD), intellectual disability, or autism.
We found this trial at
1
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185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
Phone: 617-724-4167
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