An Adaptive Algorithm-Based Approach to Treatment for Adolescent Depression
| Status: | Recruiting |
|---|---|
| Conditions: | Depression, Depression |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 12 - 18 |
| Updated: | 4/27/2018 |
| Start Date: | February 26, 2018 |
| End Date: | October 2022 |
| Contact: | Meredith Gunlicks-Stoessel, Ph.D. |
| Email: | mgunlick@umn.edu |
| Phone: | 612-273-9844 |
The purpose of this study is to evaluate the effectiveness of two adaptive treatment
strategies (ATSs) for adolescent depression. The ATSs include delivery of an evidence-based
psychotherapy (interpersonal psychotherapy for depressed adolescents, IPT-A), systematic
symptom monitoring, and an empirically-derived algorithm that specifies whether, when, and
how to augment IPT-A. Two hundred depressed adolescents (age 12-18) will be recruited to
participate in a 16-week sequential multiple assignment randomized trial conducted in
outpatient community mental health clinics. Adolescents will be randomized to the IPT-A ATS
condition or the community clinic's usual care (UC). Adolescents in the IPT-A ATS condition
who are insufficient responders will be randomized a second time to the addition of a
selective serotonin reuptake inhibitor (SSRI) or more intensive IPT-A (delivered twice per
week). Research assessments will be administered at baseline and at weeks 4, 8, 12, 16, and
36.
strategies (ATSs) for adolescent depression. The ATSs include delivery of an evidence-based
psychotherapy (interpersonal psychotherapy for depressed adolescents, IPT-A), systematic
symptom monitoring, and an empirically-derived algorithm that specifies whether, when, and
how to augment IPT-A. Two hundred depressed adolescents (age 12-18) will be recruited to
participate in a 16-week sequential multiple assignment randomized trial conducted in
outpatient community mental health clinics. Adolescents will be randomized to the IPT-A ATS
condition or the community clinic's usual care (UC). Adolescents in the IPT-A ATS condition
who are insufficient responders will be randomized a second time to the addition of a
selective serotonin reuptake inhibitor (SSRI) or more intensive IPT-A (delivered twice per
week). Research assessments will be administered at baseline and at weeks 4, 8, 12, 16, and
36.
Inclusion Criteria:
- Meet DSM-V criteria for a primary diagnosis of Major Depressive Disorder, Persistent
Depressive Disorder, or Depressive Disorder NEC
- Current significant depressive symptoms (based on Children's Depression Rating Scale -
Revised [CDRS-R] & Beck Depression Inventory-II [BDI-II])
- Current impairment in psychosocial functioning (based on Children's Global Assessment
Scale [CGAS])
Exclusion Criteria:
- Non English-speaking
- Meet DSM-V criteria for bipolar disorder, psychosis, anorexia nervosa, substance use
disorder, autism spectrum disorder, or intellectual disability disorder.
- Adolescents who are actively suicidal with a plan and/or intent who are assessed to
need a higher level of care than outpatient treatment due to safety risk will be
referred for appropriate level of stabilization. Once stabilized, the adolescent can
be re-evaluated for eligibility to participate in the study.
- Currently taking medication for a psychiatric diagnosis other than ADHD
- Females who are pregnant, breastfeeding, or having unprotected sexual intercourse, due
to the possibility of randomization to treatment with an SSRI.
We found this trial at
1
site
Minneapolis, Minnesota 55415
Phone: 612-624-8839
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