Yttrium Y 90 Glass Microspheres PET/CT in Imaging Patients With Liver Tumors
| Status: | Recruiting |
|---|---|
| Conditions: | Liver Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 6/15/2018 |
| Start Date: | February 15, 2017 |
| End Date: | February 15, 2020 |
| Contact: | Risa Jiron |
| Email: | rjiron@stanford.edu |
| Phone: | 650-736-1598 |
High Quality Imaging and Dosimetry of Yttrium-90 (90Y) SIRT Using a Digital PET/CT
This clinical trial studies how well yttrium Y 90 glass microspheres positron emission
tomography (PET)/computed tomography (CT) works in imaging patients with liver tumors. Images
produced by PET/CT may provide better information about the distribution of particles, such
as yttrium Y 90 glass microspheres, delivered for selective internal radiation therapy (SIRT)
compared to the technetium Tc-99m albumin aggregated single photon emission computed
tomography (SPECT)/CT images.
tomography (PET)/computed tomography (CT) works in imaging patients with liver tumors. Images
produced by PET/CT may provide better information about the distribution of particles, such
as yttrium Y 90 glass microspheres, delivered for selective internal radiation therapy (SIRT)
compared to the technetium Tc-99m albumin aggregated single photon emission computed
tomography (SPECT)/CT images.
PRIMARY OBJECTIVES:
I. To evaluate the image quality of yttrium Y 90 glass microspheres (90Y) PET/CT post SIRT
images as compared to technetium Tc-99m albumin aggregated (99mTc MAA) SPECT/CT.
SECONDARY OBJECTIVES:
I. To determine the superior accuracy in both distribution and dosimetry of 90Y PET/CT post
SIRT imaging compared to 99mTc MAA planar and SPECT/CT imaging.
OUTLINE:
Immediately after standard of care SIRT, patients receive yttrium Y 90 glass microspheres and
undergo PET/CT over 30 minutes.
I. To evaluate the image quality of yttrium Y 90 glass microspheres (90Y) PET/CT post SIRT
images as compared to technetium Tc-99m albumin aggregated (99mTc MAA) SPECT/CT.
SECONDARY OBJECTIVES:
I. To determine the superior accuracy in both distribution and dosimetry of 90Y PET/CT post
SIRT imaging compared to 99mTc MAA planar and SPECT/CT imaging.
OUTLINE:
Immediately after standard of care SIRT, patients receive yttrium Y 90 glass microspheres and
undergo PET/CT over 30 minutes.
Inclusion Criteria:
- Patient provides written informed consent
- Patient is referred for 90Y SIRT radioembolization of liver tumor(s)
- Patient is capable of complying with study procedures
- Patient is able to remain still for duration of imaging procedure (approximately 30
minutes total for digital PET/CT)
Exclusion Criteria:
- Patient is pregnant or nursing
We found this trial at
1
site
Palo Alto, California 94304
Principal Investigator: Shyam Srinivas
Phone: 650-736-1598
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