Trial of AB-110 in Adults With Hematologic Malignancies Undergoing Cord Blood Transplantation

Conditions:Blood Cancer, Blood Cancer, Blood Cancer, Blood Cancer
Therapuetic Areas:Oncology
Age Range:18 - 60
Start Date:April 24, 2018
End Date:March 2022
Contact:Gayle Bresnahan

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A Phase 1 Open-Label, Multi-Center Trial of AB-110 in Adults With Hematologic Malignancies Undergoing Cord

A phase 1b, open label, multi-center trial of AB-110 in adults with hematologic malignancies,
including acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), and
myelodysplasia (MDS) undergoing cord blood transplantation. Subjects will receive
unmanipulated cord blood (UCB) and AB-110 expanded CD34 enriched hematopoietic progenitor
cells (HSPC).

Inclusion Criteria:

- Patients must have received some immunosuppressive chemotherapy in the preceding 3

- Acute myelogenous leukemia (AML):

1. Complete first remission (CR1) at high risk for relapse

2. Complete second remission (CR2).

3. No documented myelofibrosis at screening marrow biopsy

- Acute lymphoblastic leukemia (ALL):

1. Complete first remission (CR1) at high risk for relapse

2. Complete second remission (CR2).

- Other acute leukemias that are of ambiguous lineage or of other types

- Any acute leukemia with marrow aplasia or without adequate count recovery.

- Myelodysplastic Syndrome (MDS)

- Karnofsky score > 70 %.

- Calculated creatinine clearance > 60 ml/min.

- Bilirubin < 1.5 mg/dL, ALT < 3 x upper limit of normal

- Pulmonary function (FVC, FEV1 and corrected DLCO) > 50% predicted.

- Left ventricular ejection fraction > 50%.

- Albumin > 3.0 g/dL.

- Negative antiviral serology:

- Negative human immunodeficiency virus (HIV) antibody.

- Negative human T-lymphotropic virus (HTLV)-1 and 2 antibodies.

- Negative hepatitis B surface antigen (HBsAg) and undetectable hepatitis B virus (HBV)

- Negative hepatitis C virus (HCV) antibody or negative HCV ribonucleic acid (RNA)

- For female subjects of childbearing potential:

1. A negative serum pregnancy test

2. Willing to use contraception throughout the study period.

- Male subjects must be willing to use a recommended method of contraception throughout
the study period, and to refrain from sperm donation throughout the study period.

- Two appropriate CB units identified for the subject.

- In the judgment of the investigator, participation in the protocol offers an
acceptable benefit-to-risk ratio when considering current disease status, medical
condition, and the potential benefits and risks of alternative treatments for the
subject's cancer.

- Willingness and ability to comply with scheduled visits, drug administration plan,
protocol-specified laboratory tests, other study procedures, and study restrictions.

- Evidence of a signed informed written consent

Exclusion Criteria:

- Pregnancy or breastfeeding.

- Current active, uncontrolled bacterial, viral, or fungal infection

- Prior allogeneic or autologous HCT at any time.

- Active malignancy other than the one for which AB-110 transplant is being performed
within 12 months of enrollment.

- Any identified and available 10/10 HLA-matched related donor or 10/10 HLA-matched
unrelated donor.

- Have evidence of recipient donor specific anti-HLA antibodies.

- Active central nervous system (CNS) disease at time of screening.

- Documented allergy to DMSO, mouse or bovine proteins, or iron.

- Subject has other conditions that in the opinion of the investigator would place the
subject at increased risk for toxicity by participation in the study.

- Psychiatric condition making the patient unlikely to comply with protocol therapy,
required tests and follow-up.
We found this trial at
1500 E Duarte Rd
Duarte, California 91010
(626) 256-4673
Principal Investigator: Chatchada Karanes, MD
Phone: 626-256-4673
City of Hope Comprehensive Cancer Center City of Hope is a leading research and treatment...
Duarte, CA
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Aurora, Colorado 80045
Principal Investigator: Jonathan Gutman, MD
Phone: 720-848-0628
Aurora, CO
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1275 York Ave
New York, New York 10021
(212) 639-2000
Principal Investigator: Juliet Barker, MBBS
Phone: 646-888-8570
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
New York, NY
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