Angiotensin II and Chronic Inflammation in Persistent Microvascular Dysfunction Following Preeclampsia
| Status: | Recruiting |
|---|---|
| Conditions: | Women's Studies |
| Therapuetic Areas: | Reproductive |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/17/2018 |
| Start Date: | August 23, 2017 |
| End Date: | March 2023 |
| Contact: | Anna Stanhewicz, PhD |
| Email: | axs1056@psu.edu |
| Phone: | 814-865-1235 |
Role of Angiotensin II and Chronic Inflammation in Persistent Microvascular Dysfunction Following Preeclamptic Pregnancy
Women who develop preeclampsia during pregnancy are more likely to develop cardiovascular
disease later in life, even if they are otherwise healthy. The reason why this occurs is
unclear but may be related to blood vessel damage and increased inflammation that occurs
during the preeclamptic pregnancy and persists postpartum. The purpose of this investigation
is to 1) determine the mechanisms contributing to this lasting blood vessel damage and
chronic inflammation, and to 2) identify factors (both physiological and pharmacological)
that mitigate these negative effects in order to inform better clinical management of
cardiovascular disease risk in women who have had preeclampsia.
disease later in life, even if they are otherwise healthy. The reason why this occurs is
unclear but may be related to blood vessel damage and increased inflammation that occurs
during the preeclamptic pregnancy and persists postpartum. The purpose of this investigation
is to 1) determine the mechanisms contributing to this lasting blood vessel damage and
chronic inflammation, and to 2) identify factors (both physiological and pharmacological)
that mitigate these negative effects in order to inform better clinical management of
cardiovascular disease risk in women who have had preeclampsia.
Inclusion Criteria:
- Post-partum women who have delivered within one year and who have had a preeclamptic
pregnancy diagnosed by their obstetrician before 34 weeks of gestation and confirmed
according to the American College of Obstetricians and Gynecologists criteria for
severe preeclampsia. [This information will be self-reported by the subjects.]
- Post-partum women who have delivered within one year and who have had a normal
pregnancy.
- 18 years and older.
Exclusion Criteria:
- skin diseases
- current tobacco use
- diagnosed or suspected hepatic or metabolic disease
- statin or other cholesterol-lowering medication
- history of hypertension prior to pregnancy
- history of gestational diabetes
- current pregnancy
- allergy to aspirin or NSAIDs or known allergy to materials used during the experiment
(e.g. latex)
- renal disease, bleeding disorders and history of gastrointestinal bleeding.
- Known allergies to study drugs
- Taking blood thinners, aspirin or NSAIDS.
- Women who choose to breastfeed will not participate in any parts of the project that
include salsalate.
We found this trial at
1
site
State College, Pennsylvania 16802
Principal Investigator: Anna Stanhewicz, PhD
Phone: 814-865-1235
Click here to add this to my saved trials
