Oral Vancomycin to Prevent Recurrent C Difficile Infection With Antibiotics
| Status: | Enrolling by invitation |
|---|---|
| Conditions: | Infectious Disease |
| Therapuetic Areas: | Immunology / Infectious Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/17/2018 |
| Start Date: | March 8, 2018 |
| End Date: | March 2019 |
Efficacy of Prophylactic Oral Vancomycin in Preventing Recurrent Clostridium Difficile Infection in Hospitalized Patients Requiring Antibiotics
This study will assess the efficacy of oral vancomycin prophylaxis in preventing recurrent
Clostridium difficile infection in hospitalized patients requiring oral or intravenous
antibiotics for a suspected or confirmed bacterial infection.
Clostridium difficile infection in hospitalized patients requiring oral or intravenous
antibiotics for a suspected or confirmed bacterial infection.
Inclusion Criteria:
1. Age ≥18 years
2. Previous CDI diagnosis (diarrhea- passage of ≥3 loose stools in ≤24 hours and positive
PCR for toxigenic C. difficile)
3. Current admission with a suspected or a confirmed bacterial infection requiring
antibiotics
Exclusion Criteria:
1. Active chronic diarrheal illness (eg, Crohn's disease, ulcerative colitis, short bowel
syndrome)
2. Previous adverse reactions to oral vancomycin
3. Requiring metronidazole during hospitalization
4. Known pregnancy
5. Expected survival <72 hours
6. Patients receiving antibiotics only for surgical prophylaxis
7. Patients who received prophylactic oral vancomycin for the current antibiotic course
prior to enrollment in the study
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