Identify Biomarkers of Tobacco Exposure and Nicotine Uptake From JUUL 5% in Adult Smokers

This study will serve as a clinical evaluation of the exclusive use of selected JUUL ENDS,
with the purpose of gaining an understanding of toxicant exposure.

Key Inclusion Criteria:

1. Healthy, adult, male or female smoker, 21 to 65 years of age.

2. Has been a smoker for at least 12 months prior to Screening.

3. Currently smokes an average of 10 cigarettes each day.

4. Has a positive urine cotinine (≥ 500 ng/mL).

5. Has an exhaled carbon monoxide (CO) > 12 ppm.

6. A female subject of childbearing potential must have been using contraception and
agree to continue using it through completion of the study:

7. Provides voluntary consent to participate in this study documented on the signed
informed consent form (ICF).

Key Exclusion Criteria

1. Has a history or presence of clinically significant conditions.

2. Has a body mass index (BMI) > 40 kg/m2 or < 18 kg/m2 at Screen

3. Has a history of drug or alcohol abuse

4. Has an estimated creatinine clearance < 80 mL/minute

5. If female, the subject is pregnant, lactating, or intends to become pregnant during
the time period from Screening through the end of study.

6. Has used nicotine-containing products other than manufactured cigarettes within 14days
of screening.

7. Is planning to quit smoking during the study, planning to quit within 3 months
following Day 1