A Cognitive Self-Management Intervention for Persons With Multiple Sclerosis: Adapting Web-based Technology

The primary objective of this study is to develop and pilot test an innovative cognitive
self-management intervention for PwMS delivered via web-based video conferencing. Data
derived from interviews will be used to guide the adaptation of Stuifbergen's 8-week Memory,
Attention, and Problem-Solving Skills in MS (MAPSS-MS) intervention to be delivered via
web-based video conferencing. The adapted MAPSS-MS intervention will be feasibility tested in
small groups of PwMS. Outcome variables include: (1) neurocognitive function assessed using
the NIH Toolbox®, a comprehensive set of psychometrically sound neuro-behavioral measures
that quickly assesses cognitive functions using an iPad, (2) objective PA and sleep using
Actigraph™ accelerometers, (3) self-reported sleep, depression, and fatigue using the
Patient-Reported Outcome Measurement Information System (PROMIS), and (4) MS specific
self-management using the Multiple Sclerosis Self-Management Scale (MSSM). Community-residing
PwMS, age 21 to 70, will be recruited from Central Texas to participate in Phase 1 interviews
(n=5) and Phase 2 pilot testing (n=20) of the adapted version of the 8-week MAPSS-MS
cognitive self-management intervention emphasizing PA delivered via web-based video
conferencing. In Phase 2 pilot testing (n=20), an intervention group (n=10) will be compared
to an "enhanced usual care" control group (n=10).

Inclusion Criteria:

- Diagnosis of clinically definite MS documented by their healthcare provider

- Age 21 to 70

- Capable of understanding and complying with the study protocol

- Able to read and write in English

- Stable disease at the time of entry into the study (relapse free for at least 90 days)

- Willing to participate in an 8-week study promoting physical activity, MS
self-management and compensatory cognitive strategies, and data collection

- Have subjective concerns about their cognitive functioning (score ≥ 10 on the 20-item
Perceived Deficits Questionnaire)

- Any gender

- Any ethnic/racial group

Exclusion Criteria:

- Currently pregnant or plan to be

- Diagnosed with cardiovascular or respiratory disease, other medical causes of dementia
or other neurological disorders that may impact cognition or emotions

- Evidence of major psychiatric disorder

- Major functional limitations that preclude them from participating in the study