Vascular CT Assessment of Structural Autograft and Allograft Healing

The purpose of this study is to investigate quantitative vascular cone beam CT(CBCT) in a
clinical pilot of patients that have received a structural allograft for bone cancer or a
vascularized structural autograft for bone cancer or traumatic injury. Development of a
minimally invasive, longitudinal outcome measure to quantify intramedullary vascular volume
and cortical bone volume of structural allografts in patients is required to translate
"revitalizing" structural allograft in clinical trials. Our novel vascular CBCT will be able
to demonstrate the significant differences between vascularized fibular autografts vs.
structural allografts in patients that will undergo structural grafting. These data will be
used to devise a power calculation for a definitive clinical trial to evaluate the efficacy
of the revitalizing allograft.

Inclusion Criteria:

- male or female

- all races will be included

- autograft or allograft of long bone as part of treatment for bone tumor

Exclusion Criteria:

- pregnancy

- patients with a history of IV contrast reactions

- contraindication to use of epinephrine or diphenhydramine

- hypertyroidism or history of sensitivity to iodine

- kidney disease (abnormal urinalysis or calculaged GFR) or poor hydration due to poor
intake or other causes