The Neural Basis for Frontotemporal Degeneration
| Status: | Recruiting |
|---|---|
| Conditions: | Other Indications, Neurology |
| Therapuetic Areas: | Neurology, Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/17/2018 |
| Start Date: | July 1, 2003 |
| End Date: | December 31, 2026 |
| Contact: | Christine Ray, MS |
| Email: | rayc@pennmedicine.upenn.edu |
| Phone: | 215-349-5863 |
This is an observational study that aims to better understand the genetic causes of
frontotemporal degeneration (FTD), Multiple Systems Atrophy (MSA), and Progressive
Supranuclear Palsy (PSP). It is hoped the information gathered in this study will help lead
to better diagnostics and future treatments.
frontotemporal degeneration (FTD), Multiple Systems Atrophy (MSA), and Progressive
Supranuclear Palsy (PSP). It is hoped the information gathered in this study will help lead
to better diagnostics and future treatments.
Comparative and longitudinal studies reveal clinical differences between subgroups of
patients with frontotemporal dementia (FTD), including Progressive Non-fluent Aphasia (PNFA),
Semantic Dementia (SD), patients with a disorder of social comportment and personality (SOC),
and non-aphasic patients with executive dysfunction (EXEC). MRI studies of cortical atrophy
and fMRI studies show correlated neural defects in FTD subgroups. We will obtain converging
evidence from multiple sources to test hypotheses about the neural basis for cognitive
functions such as semantic memory, grammatical processing, and social functioning in these
FTD subgroups, while we improve clinical care for these patients. Recent studies have linked
progressive supra nuclear palsy (PSP) and multiple systems atrophy (MSA) to FTD. We will
obtain comparable neuropsychological and biomarker data in order to compare these patient
groups.
patients with frontotemporal dementia (FTD), including Progressive Non-fluent Aphasia (PNFA),
Semantic Dementia (SD), patients with a disorder of social comportment and personality (SOC),
and non-aphasic patients with executive dysfunction (EXEC). MRI studies of cortical atrophy
and fMRI studies show correlated neural defects in FTD subgroups. We will obtain converging
evidence from multiple sources to test hypotheses about the neural basis for cognitive
functions such as semantic memory, grammatical processing, and social functioning in these
FTD subgroups, while we improve clinical care for these patients. Recent studies have linked
progressive supra nuclear palsy (PSP) and multiple systems atrophy (MSA) to FTD. We will
obtain comparable neuropsychological and biomarker data in order to compare these patient
groups.
Inclusion Criteria:
- Individuals who have been diagnosed with FTD, PSP, and MSA
Exclusion Criteria:
- Individuals under 18 years of age
- People with pacemakers or certain metallic implants
- pregnant women
We found this trial at
1
site
3451 Walnut St
Philadelphia, Pennsylvania 19104
Philadelphia, Pennsylvania 19104
1 (215) 898-5000
Principal Investigator: Murray Grossman, PhD, MD
Phone: 215-349-5863
Univ of Pennsylvania Penn has a long and proud tradition of intellectual rigor and pursuit...
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