Cerebral Hemodynamic Effects of Hypertonic Solutions in Severely Head-Injured Patients
| Status: | Archived |
|---|---|
| Conditions: | High Blood Pressure (Hypertension), Neurology |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Neurology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
This is a clinical study comparing the physiologic effects of two hypertonic solutions
(mannitol, hypertonic saline) with a particular emphasis on changes in cerebral blood flow
in patients with intracranial hypertension following serious traumatic brain injury (TBI).
This is a study comparing effects of two hypertonic solutions (mannitol, 6.4% hypertonic
saline) on intracranial hypertension, cerebral blood flow, serum/urine osmolarity in
patients with increased intracranial pressure caused by traumatic brain injury. The study
is conducted during first 72 hours after the injury without any interference with standard
medical treatment as performed at the institution. When the hypertonic solution is indicated
by caregiver, the study team is informed and performs a set of physiologic bedside
measurements including evaluation of cerebral blood flow and changes in plasma and urine
osmolarity. The study is noninvasive and the study protocol does not hamper, in any way,
standard care of treatment for these patients.
We found this trial at
1
site
San Antonio, Texas 78229
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