Suprachoroidal Injection of Triamcinolone Acetonide With IVT Anti-VEGF in Subjects With Macular Edema Following RVO



Status:Terminated
Conditions:Cardiology, Ocular, Ocular
Therapuetic Areas:Cardiology / Vascular Diseases, Ophthalmology
Healthy:No
Age Range:18 - Any
Updated:1/11/2019
Start Date:March 5, 2018
End Date:December 18, 2018

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A RANDOMIZED, MASKED, CONTROLLED TRIAL TO STUDY THE SAFETY AND EFFICACY OF SUPRACHOROIDAL CLS-TA IN COMBINATION WITH AN INTRAVITREAL ANTI-VEGF AGENT IN SUBJECTS WITH RETINAL VEIN OCCLUSION

This Phase 3, multicenter, randomized, masked, controlled, parallel group study is designed
to demonstrate that suprachoroidal (SC) CLS-TA administered with intravitreal (IVT) anti-VEGF
agent in subjects with treatment naive RVO is superior to IVT anti-VEGF agent used alone.

A Randomized, Masked, Controlled Trial to Study the Safety and Efficacy of Suprachoroidal
CLS-TA With Intravitreal Anti-VEGF Agent in Subjects With Retinal Vein Occlusion

Inclusion Criteria:

- Has a clinical diagnosis of RVO in the study eye

- Has a CST of ≥ 300 µm in the study eye

- Has an ETDRS BCVA score of ≥ 20 letters read and ≤ 70 letters read in the study eye

- Is naïve to local pharmacologic treatment for RVO in the study eye

Exclusion Criteria:

- Any active ocular disease or infection in the study eye other than RVO

- History of glaucoma, intraocular pressure > 21 mmHg or ocular hypertension requiring
more than one medication

- Any uncontrolled systemic disease that, in the opinion of the Investigator, would
preclude participation in the study

- Any evidence of neovascularization in the study eye
We found this trial at
73
sites
Hagerstown, Maryland 21740
2241
mi
from 91732
Hagerstown, MD
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98-1079 Moanalua Road
'Aiea, Hawaii 96701
2575
mi
from 91732
'Aiea, HI
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669 Dean Street
Albury, New South Wales 2640
7800
mi
from 91732
Albury,
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Arcadia, California 91006
4
mi
from 91732
Arcadia, CA
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Arlington, Texas 76012
1207
mi
from 91732
Arlington, TX
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Austin, Texas 78705
1211
mi
from 91732
Austin, TX
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Austin, Texas 78705
1211
mi
from 91732
Austin, TX
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Baltimore, Maryland 21209
2298
mi
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Baltimore, MD
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Baltimore, Maryland 21204
?
mi
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Baltimore, MD
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Beverly Hills, California 90211
?
mi
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Beverly Hills, CA
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Bloomington, Illinois 61704
1650
mi
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Bloomington, IL
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Boston, Massachusetts 02114
2578
mi
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Boston, MA
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Boynton Beach, Florida
2309
mi
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Boynton Beach, FL
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Camp Hill, Pennsylvania 17011
2281
mi
from 91732
Camp Hill, PA
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Campbell, California 95008
313
mi
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Campbell, CA
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Chevy Chase, Maryland 20815
2278
mi
from 91732
Chevy Chase, MD
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Coral Springs, Florida 33067
?
mi
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Coral Springs, FL
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Dallas, Texas 75231
1226
mi
from 91732
Dallas, TX
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Fairfax, Virginia 22031
2267
mi
from 91732
Fairfax, VA
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1224 Graham Road
Florissant, Missouri 63031
1566
mi
from 91732
Florissant, MO
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Fort Myers, Florida 33912
2209
mi
from 91732
Fort Myers, FL
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Fullerton, California 92835
12
mi
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Fullerton, CA
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Glendale, California 91203
15
mi
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Glendale, CA
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Grand Rapids, Michigan 49525
1843
mi
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Grand Rapids, MI
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Grand Rapids, Michigan 45946
1839
mi
from 91732
Grand Rapids, MI
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Houston, Texas 77025
1357
mi
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Houston, TX
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Houston, Texas 77030
1357
mi
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Houston, TX
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Las Vegas, Nevada
217
mi
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Las Vegas, NV
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Leawood, Kansas
1338
mi
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Leawood, KS
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Los Angeles, California 90017
24
mi
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Los Angeles, CA
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Lynbrook, New York 11563
2450
mi
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Lynbrook, NY
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McAllen, Texas 78503
1297
mi
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McAllen, TX
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?
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Melbourne, FL
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Middleburg Heights, Ohio 44130
2025
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Middleburg Heights, OH
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Morgantown, West Virginia 26506
?
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Morgantown, WV
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2485 Hospital Drive
Mountain View, California 94040
322
mi
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Mountain View, CA
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400 Bayonet Street
New London, Connecticut 06320
2528
mi
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New London, CT
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Oak Forest, Illinois 60452
?
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Oak Forest, IL
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Oklahoma City, Oklahoma 73104
1165
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Oklahoma City, OK
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Orlando, Florida 32805
2183
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Orlando, FL
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Paducah, Kentucky 42001
1659
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Paducah, KY
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Palo Alto, California 94303
?
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Palo Alto, CA
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Phoenix, Arizona 85014
344
mi
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Phoenix, AZ
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Pinellas Park, Florida 33782
2125
mi
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Pinellas Park, FL
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Plano, Texas 75093
1219
mi
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Plano, TX
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Rapid City, South Dakota 57701
1049
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Rapid City, SD
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Redlands, California 92374
49
mi
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Redlands, CA
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Reno, Nevada 89502
385
mi
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Reno, NV
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Rochester, New York 14618
2248
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Rochester, NY
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Royal Oak, Michigan 48073
1961
mi
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Royal Oak, MI
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Sacramento, California 95819
366
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Sacramento, CA
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4344 Central Avenue North
Saint Petersburg, Florida 33711
2127
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Saint Petersburg, FL
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Salt Lake City, Utah 84107
570
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Salt Lake City, UT
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San Antonio, Texas 78215
1188
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San Antonio, TX
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San Antonio, Texas 78240
1188
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San Antonio, TX
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San Antonio, Texas 78240
1188
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San Antonio, TX
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Shirley, New York 11967
2491
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Shirley, NY
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Southfield, Michigan 48034
1958
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Southfield, MI
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Springfield, Illinois 62704
?
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Springfield, IL
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3640 Main Street
Springfield, Massachusetts 01107
2499
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Springfield, MA
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Stuart, Florida 34994
?
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Stuart, FL
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2319
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Syracuse, NY
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Tallahassee, Florida 32308
?
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Tallahassee, FL
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The Woodlands, Texas 77384
1340
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The Woodlands, TX
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Towson, Maryland 21204
2300
mi
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Towson, MD
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Traverse City, Michigan 49586
1864
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Traverse City, MI
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Tucson, Arizona 85704
426
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Tucson, AZ
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Tucson, Arizona 85724
427
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Tucson, AZ
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Whittier, California 90603
9
mi
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Whittier, CA
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1182
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Wichita, KS
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Wichita, Kansas 67226
1181
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Wichita, KS
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Willow Park, Texas 76087
1355
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Willow Park, TX
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Winter Haven, Florida 33880
2176
mi
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Winter Haven, FL
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