The Neural Correlates of Cannabis Use



Status:Recruiting
Conditions:Healthy Studies, Psychiatric
Therapuetic Areas:Psychiatry / Psychology, Other
Healthy:No
Age Range:18 - 55
Updated:1/13/2019
Start Date:December 2016
End Date:July 2021
Contact:Patrick Skosnik, PhD
Email:patrick.skosnik@yale.edu
Phone:203-932-5711

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Trial Summary
Trial Overview
Inclusion Criteria
The purpose of this research study is to determine the temporal course of recovery of CB1R
availability and neural oscillations, in cannabis-dependent individuals at baseline,
following 48 hour confirmed inpatient abstinence and after four weeks confirmed abstinence.
This research will also examine associations between CB1R availability, neural oscillations
and cognitive function.

The purpose of this research study is to determine the temporal course of recovery of CB1R
availability and neural oscillations, in cannabis-dependent individuals at baseline,
following 48 hour confirmed inpatient abstinence and after four weeks confirmed outpatient
abstinence (confirmed by tracking creatinine adjusted urine THC-COOH levels). This research
will also examine associations between CB1R availability, neural oscillations and cognitive
function using [11-C]OMAR PET imaging and electroencephalography.

Inclusion Criteria: Cannabis Dependent Subjects

- Current cannabis consumption

- Willing to abstain from cannabis use for four weeks

Inclusion Criteria for Healthy Controls

- No current cannabis consumption

Exclusion Criteria:

- MRI metal exclusions and claustrophobia

- Education completed is less than 12 years
We found this trial at
1
site
Conneticut Mental Health Center
New Haven, Connecticut 06519
Principal Investigator: Patrick Skosnik, PhD
Phone: 203-974-7775
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mi
from
New Haven, CT
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