Dietary Salt Intake and Vascular Function
| Status: | Completed |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - 45 |
| Updated: | 11/30/-0001 |
| Start Date: | March 2005 |
| End Date: | July 2013 |
| Contact: | Kaitlyn Barnes, BA |
| Email: | RBLResearchGroup@partners.org |
| Phone: | 617-724-3504 |
The purpose of this study is to look at the effects of high- and low-salt diets on blood
vessel function in healthy subjects.
Inclusion Criteria:
1. Healthy male, African-American volunteers,
2. 18-45 years of age,
3. No personal or first degree relative with hypertension or diabetes,
4. Blood pressure <130/85 mmHg and > 90/60 at the screening visit,
5. Body mass index <30 kg/m2,
6. No clinically significant abnormalities on screening tests (complete blood count,
serum electrolytes, liver enzymes, thyroid stimulating hormone, urinalysis and
electrocardiogram).
Exclusion Criteria:
1. Alcohol intake >1 beverage/night,
2. Smoking,
3. Recreational drug use,
4. Personal history of coronary disease, diabetes, hypertension, stroke, kidney disease,
or illness requiring overnight hospitalization in the past 6 months,
5. Prescription or herbal medication use,
6. Ischemic changes on resting electrocardiogram,
7. Known hypersensitivity to any of the study drugs,
8. Other active medical problems detected by examination or laboratory testing.
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