Clearance of 25-hydroxyvitamin D in Chronic Kidney Disease
| Status: | Recruiting |
|---|---|
| Conditions: | Renal Impairment / Chronic Kidney Disease |
| Therapuetic Areas: | Nephrology / Urology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 10/13/2018 |
| Start Date: | March 1, 2017 |
| End Date: | December 2020 |
| Contact: | Laura Curtin |
| Email: | LCurtin@Nephrology.washington.edu |
| Phone: | 2062213938 |
The goal of this study is to better understand vitamin D catabolism and how it is affected by
CKD and race. Specifically, the study team will evaluate the metabolic clearance of
25-hydroxyvitamin D3 in individuals with varying degrees of CKD and among participants who
self-report race as Caucasian, African American or African. The long-term goal of this work
is to enhance the clinical evaluation and treatment of impaired vitamin D metabolism.
CKD and race. Specifically, the study team will evaluate the metabolic clearance of
25-hydroxyvitamin D3 in individuals with varying degrees of CKD and among participants who
self-report race as Caucasian, African American or African. The long-term goal of this work
is to enhance the clinical evaluation and treatment of impaired vitamin D metabolism.
Inclusion Criteria:
- Age ≥ 18 years
- Self-reported race Caucasian, African American, or African
- Serum total 25(OH)D 10-50 ng/mL
- Estimated GFR:
- 60 mL/min/1.73m2 (N=40) 15-45 mL/min/1.73m2 (N=40) <15 mL/min/1.73m2, treated
with hemodialysis (N=40)
Exclusion Criteria:
- Primary hyperparathyroidism
- Gastric bypass
- Tuberculosis or sarcoidosis
- Current pregnancy
- Child-Pugh Class B or C cirrhosis (i.e. cirrhosis with ascites, hepatic
encephalopathy, bilirubin >=2 mg/dL, serum albumin <=3.5 g/dL, or PT >= 4 seconds)
- Use of vitamin D3, or vitamin D2 supplements exceeding a mean daily dose of 400 IU,
within 3 months (wash-out allowed)
- Use of 1,25(OH)2D3 or an analogue, calcimimetics, or medications known to induce
CYP24A1 within 4 weeks (wash-out allowed)
- Serum calcium > 10.1 mg/dL
- Hemoglobin < 10 g/dL
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