Effect of Elderberry Juice on Cognition and Inflammation in Patients With Mild Cognitive Impairment
| Status: | Recruiting |
|---|---|
| Conditions: | Cognitive Studies, Cognitive Studies |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 50 - Any |
| Updated: | 4/17/2018 |
| Start Date: | September 2016 |
| End Date: | April 2019 |
| Contact: | David Q Beversdorf, MD |
| Email: | beversdorfd@health.missouri.edu |
| Phone: | 573-882-6081 |
Elderberries (Sambuci fructus) have been shown in a number of studies to have significant
anti-inflammatory and antioxidant effects. Multiple human and animal studies have supported
the anti-inflammatory and antioxidant effects of elderberry preparations and it has been used
in natural medicine for hundreds of years. Studies examining factors that may decrease the
risk of Alzheimer's disease have revealed that drinking juices with similar properties to
elderberries is one of the most reliable way to decrease risk. As such the investigators wish
to determine the effects of elderberry juice on cognitive decline in a group of subjects at
high risk for Alzheimer's disease, those with mild cognitive impairment. Elderberry juice is
a commercially available nutritional supplement and easily available to this population.
anti-inflammatory and antioxidant effects. Multiple human and animal studies have supported
the anti-inflammatory and antioxidant effects of elderberry preparations and it has been used
in natural medicine for hundreds of years. Studies examining factors that may decrease the
risk of Alzheimer's disease have revealed that drinking juices with similar properties to
elderberries is one of the most reliable way to decrease risk. As such the investigators wish
to determine the effects of elderberry juice on cognitive decline in a group of subjects at
high risk for Alzheimer's disease, those with mild cognitive impairment. Elderberry juice is
a commercially available nutritional supplement and easily available to this population.
Inclusion Criteria:
- CDR score of 0.5
- MMSE of at least 24
- Age 50 or older
Exclusion Criteria:
- Known history of sensitivity to elderberry products.
- Diabetes.
- Bleeding disorder.
- Current Pregnancy.
- Known allergy to honeysuckle.
- Currently making changes to other drugs that might affect cognitive performance
(subjects showing the greatest cognitive decline and other signs of Alzheimer's
disease may be prescribed cholinesterase inhibitors as this is a standard of care for
Alzheimer's disease but not MCI).
- Presence of any condition the health professional believes will impair ability to
complete study procedures (ex. terminal illness, comorbid major psychiatric disorders
such as schizophrenia, or drug abuse).
- Potentially confounding neurodegenerative diseases (e.g. MS).
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