Tissue-specific Effects of Insufficient Sleep



Status:Recruiting
Conditions:Healthy Studies
Therapuetic Areas:Other
Healthy:No
Age Range:18 - 35
Updated:2/21/2018
Start Date:February 12, 2018
End Date:December 2022
Contact:Josiane L. Broussard, PhD
Email:josiane.broussard@colorado.edu
Phone:303-735-1923

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This study plans to learn more about how sleep loss impacts the way the body responds to
sugar. This work will have important implications for development of treatments and
countermeasures for people who are not able to get enough sleep for various reasons.

Participants will stay in the hospital for 6 days and will not be able to leave. Sleep habits
will be measured for 7 days before the study. A research diet that is designed to maintain
weight will be provided for 3 days before the study and during the study. Multiple tests will
be performed, including metabolic testing and muscle and fat biopsies, both when participants
first arrive and have had normal sleep and again after 4 nights of only 5 hours time in bed.
The visit takes place at the Clinical Translational Research Center (CTRC) at the University
of Colorado Denver, Anschutz Medical campus. It will take approximately 2 weeks to complete
this study.

Inclusion criteria:

1. Healthy, lean participants.

2. No regular physical activity (<20 minutes/day). No exercise will be allowed for 3 days
prior to study start.

3. Habitual sleep duration between 7-9.25h. Subjects must also be willing and able to
keep a 9h time-in-bed schedule for 1 week prior to study admission.

4. Potential subjects must have lived at Denver altitude or higher for at least 3 months
to inpatient study.

Exclusion Criteria:

1. Current or history of any clinically significant medical, psychiatric, or sleep
disorder.

2. Use or history of any drugs, medications, supplements, caffeine, and alcohol.

3. Current or history of shiftwork in six months prior to laboratory study.

4. Travel more than one time zone in three weeks prior to laboratory study.

5. Blood donation in the 30 days prior to inpatient study.
We found this trial at
1
site
13001 E 17th Pl
Aurora, Colorado 80045
(303) 724-5000
University of Colorado Anschutz Medical Campus Located in the Denver metro area near the Rocky...
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from
Aurora, CO
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