Predicting Rehabilitation Outcomes in Bilingual Aphasia Using Computational Modeling



Status:Not yet recruiting
Conditions:Neurology
Therapuetic Areas:Neurology
Healthy:No
Age Range:21 - 85
Updated:2/14/2018
Start Date:April 1, 2018
End Date:June 2021
Contact:Maria Dekhtyar, BA
Email:mardek2@bu.edu
Phone:617-353-2706

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Double-blind Randomized Trial Investigating the Use of Computational Modeling to Predict Rehabilitation Outcomes in Bilingual Aphasia

The purpose of this investigation is to implement a computational model that can predict and
optimize training and cross-language generalization patterns for bilingual persons with
aphasia (BPA). The proposed work will determine the best possible treatment program for each
individual patient even before they are rehabilitated. In addition, the computational model
allows specification of variables such as age of acquisition, language exposure/proficiency,
impairment and their systematic influence on a range of language rehabilitation outcomes.


Inclusion Criteria:

- Diagnosis of aphasia with naming deficits and concurrent lexical/semantic impairment

- At least 6 months post-onset of single, left-hemisphere stroke

- Bilingual: speaking both Spanish and English (or Chinese and English)

- Visual and auditory acuity sufficient for experimental tasks

- The ability to understand study procedures and comply with them for the entire length
of the study

Exclusion Criteria:

- Diagnosed with medical disease that could compromise participation (e.g., cancer
undergoing acute treatment, unstable diabetes, renal or hepatic insufficiency,
fluctuating systemic immunological disease such as systemic lupus erythematosis, etc.)

- Diagnosed with mental illness other than active depression Neurological condition
other than that which resulted in aphasia

- Currently taking medications that are known to exert significant effects on cognitive
processes, such as neuroleptics, steroids, anticholinesterase inhibitors, etc.

- Overt, behaviorally noticeable, attentional limitations that interfere with completing
the experimental tasks

- Current drug or alcohol use or dependence that would interfere with adherence to study
requirements, in the opinion of the principal investigator

- Proficient in more than just Spanish and English (or Chinese and English)

- Premorbid history of speech/language disorder
We found this trial at
1
site
635 Commonwealth Avenue
Boston, Massachusetts 02215
Principal Investigator: Swathi Kiran, PhD
Phone: 617-358-5478
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mi
from
Boston, MA
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